Amyloid: Friend and Foe

Neha Jain, Neal D. Hammer, Xuan Wang, Bryan A. McGuffie, Matthew R. Chapman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Amyloidogenesis is the aggregation of soluble proteins into structurally conserved fibers. Amyloid fibers are distinguished by their resistance to proteinase K, tinctorial properties and β-sheet-rich secondary structure. Amyloid formation is a hallmark of many human diseases including Alzheimer's, Huntington's and the prion diseases. Therefore, understanding amyloidogenesis will provide insights into the development of therapeutics that target these debilitating diseases. A new class of 'functional' amyloids promises a unique glimpse at how nature has harnessed the amyloid fiber to accomplish important physiological tasks. Functional amyloids are produced by organisms spanning all domains of life. Understanding how functional amyloid assembly is coordinated will provide new perspectives on what can go wrong when proteins adopt β-rich polymers. Herein we review amyloidogenesis, with special attention focused on the similarities and differences between the best characterized disease-associated amyloidogenic protein, amyloid-β (Aβ), and the formation of several functional amyloids. The implications of studying functional amyloidogenesis and the strategies organisms employ to limit exposure to toxic intermediates will also be discussed.

Original languageEnglish (US)
Title of host publicationHandbook of Infection and Alzheimer's Disease
PublisherIOS Press
Pages297-311
Number of pages15
Volume5
ISBN (Electronic)9781614997054
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameAdvances in Alzheimer's Disease
Volume5
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735

Keywords

  • Amyloid
  • amyloid-β
  • biofilms
  • neurodegeneration

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Jain, N., Hammer, N. D., Wang, X., McGuffie, B. A., & Chapman, M. R. (2017). Amyloid: Friend and Foe. In Handbook of Infection and Alzheimer's Disease (Vol. 5, pp. 297-311). (Advances in Alzheimer's Disease; Vol. 5). IOS Press. https://doi.org/10.3233/978-1-61499-706-1-297