Amphetamine infused into the ventrolateral striatum produces oral stereotypies and conditioned place preference

David A. Baker, Sheila E. Specio, Ly T L Tran-Nguyen, Janet Neisewander

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of amphetamine infused into the ventrolateral striatum (VLS) on locomotion, stereotypies, and conditioned place preference (CPP) were investigated. Five 2-day conditioning trials were conducted over 10 consecutive days. On 1 day of each trial, animals received an infusion of amphetamine (0, 2.5, 5, 10, or 20 mg/0.5 ml/side) and were placed into a distinct compartment for 30 min. On the other day, animals received sham intracranial infusions and were placed into a different compartment for 30 min. Locomotion and stereotypies were assessed following the first and last amphetamine infusions. CPP was assessed the day following the last conditioning trial. Intra-VLS infusions of amphetamine did not alter sniffing or locomotion. Acute administration of amphetamine into the VLS dose dependently produced oral stereotypies, however, tolerance developed to this effect following repeated administrations. Also, intra-VLS infusions of amphetamine dose dependently produced CPP. These results suggest that the VLS is involved in amphetamine-induced oral stereotypies and reward. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume61
Issue number1
DOIs
StatePublished - Sep 1998

Fingerprint

Amphetamine
Locomotion
Animals
Reward

Keywords

  • Amphetamine
  • Conditioned place preference
  • Locomotion
  • Oral stereotypies
  • Reward
  • Ventrolateral striatum

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Amphetamine infused into the ventrolateral striatum produces oral stereotypies and conditioned place preference. / Baker, David A.; Specio, Sheila E.; Tran-Nguyen, Ly T L; Neisewander, Janet.

In: Pharmacology Biochemistry and Behavior, Vol. 61, No. 1, 09.1998, p. 107-111.

Research output: Contribution to journalArticle

@article{0ead53f9b4fb4acc9a6955ad9e4420c4,
title = "Amphetamine infused into the ventrolateral striatum produces oral stereotypies and conditioned place preference",
abstract = "The effects of amphetamine infused into the ventrolateral striatum (VLS) on locomotion, stereotypies, and conditioned place preference (CPP) were investigated. Five 2-day conditioning trials were conducted over 10 consecutive days. On 1 day of each trial, animals received an infusion of amphetamine (0, 2.5, 5, 10, or 20 mg/0.5 ml/side) and were placed into a distinct compartment for 30 min. On the other day, animals received sham intracranial infusions and were placed into a different compartment for 30 min. Locomotion and stereotypies were assessed following the first and last amphetamine infusions. CPP was assessed the day following the last conditioning trial. Intra-VLS infusions of amphetamine did not alter sniffing or locomotion. Acute administration of amphetamine into the VLS dose dependently produced oral stereotypies, however, tolerance developed to this effect following repeated administrations. Also, intra-VLS infusions of amphetamine dose dependently produced CPP. These results suggest that the VLS is involved in amphetamine-induced oral stereotypies and reward. Copyright (C) 1998 Elsevier Science Inc.",
keywords = "Amphetamine, Conditioned place preference, Locomotion, Oral stereotypies, Reward, Ventrolateral striatum",
author = "Baker, {David A.} and Specio, {Sheila E.} and Tran-Nguyen, {Ly T L} and Janet Neisewander",
year = "1998",
month = "9",
doi = "10.1016/S0091-3057(98)00070-7",
language = "English (US)",
volume = "61",
pages = "107--111",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Amphetamine infused into the ventrolateral striatum produces oral stereotypies and conditioned place preference

AU - Baker, David A.

AU - Specio, Sheila E.

AU - Tran-Nguyen, Ly T L

AU - Neisewander, Janet

PY - 1998/9

Y1 - 1998/9

N2 - The effects of amphetamine infused into the ventrolateral striatum (VLS) on locomotion, stereotypies, and conditioned place preference (CPP) were investigated. Five 2-day conditioning trials were conducted over 10 consecutive days. On 1 day of each trial, animals received an infusion of amphetamine (0, 2.5, 5, 10, or 20 mg/0.5 ml/side) and were placed into a distinct compartment for 30 min. On the other day, animals received sham intracranial infusions and were placed into a different compartment for 30 min. Locomotion and stereotypies were assessed following the first and last amphetamine infusions. CPP was assessed the day following the last conditioning trial. Intra-VLS infusions of amphetamine did not alter sniffing or locomotion. Acute administration of amphetamine into the VLS dose dependently produced oral stereotypies, however, tolerance developed to this effect following repeated administrations. Also, intra-VLS infusions of amphetamine dose dependently produced CPP. These results suggest that the VLS is involved in amphetamine-induced oral stereotypies and reward. Copyright (C) 1998 Elsevier Science Inc.

AB - The effects of amphetamine infused into the ventrolateral striatum (VLS) on locomotion, stereotypies, and conditioned place preference (CPP) were investigated. Five 2-day conditioning trials were conducted over 10 consecutive days. On 1 day of each trial, animals received an infusion of amphetamine (0, 2.5, 5, 10, or 20 mg/0.5 ml/side) and were placed into a distinct compartment for 30 min. On the other day, animals received sham intracranial infusions and were placed into a different compartment for 30 min. Locomotion and stereotypies were assessed following the first and last amphetamine infusions. CPP was assessed the day following the last conditioning trial. Intra-VLS infusions of amphetamine did not alter sniffing or locomotion. Acute administration of amphetamine into the VLS dose dependently produced oral stereotypies, however, tolerance developed to this effect following repeated administrations. Also, intra-VLS infusions of amphetamine dose dependently produced CPP. These results suggest that the VLS is involved in amphetamine-induced oral stereotypies and reward. Copyright (C) 1998 Elsevier Science Inc.

KW - Amphetamine

KW - Conditioned place preference

KW - Locomotion

KW - Oral stereotypies

KW - Reward

KW - Ventrolateral striatum

UR - http://www.scopus.com/inward/record.url?scp=0031721041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031721041&partnerID=8YFLogxK

U2 - 10.1016/S0091-3057(98)00070-7

DO - 10.1016/S0091-3057(98)00070-7

M3 - Article

C2 - 9715812

AN - SCOPUS:0031721041

VL - 61

SP - 107

EP - 111

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 1

ER -