Amphetamine infused into the ventrolateral striatum produces oral stereotypies and conditioned place preference

David A. Baker, Sheila E. Specio, Ly T L Tran-Nguyen, Janet Neisewander

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The effects of amphetamine infused into the ventrolateral striatum (VLS) on locomotion, stereotypies, and conditioned place preference (CPP) were investigated. Five 2-day conditioning trials were conducted over 10 consecutive days. On 1 day of each trial, animals received an infusion of amphetamine (0, 2.5, 5, 10, or 20 mg/0.5 ml/side) and were placed into a distinct compartment for 30 min. On the other day, animals received sham intracranial infusions and were placed into a different compartment for 30 min. Locomotion and stereotypies were assessed following the first and last amphetamine infusions. CPP was assessed the day following the last conditioning trial. Intra-VLS infusions of amphetamine did not alter sniffing or locomotion. Acute administration of amphetamine into the VLS dose dependently produced oral stereotypies, however, tolerance developed to this effect following repeated administrations. Also, intra-VLS infusions of amphetamine dose dependently produced CPP. These results suggest that the VLS is involved in amphetamine-induced oral stereotypies and reward. Copyright (C) 1998 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalPharmacology Biochemistry and Behavior
Issue number1
StatePublished - Sep 1998


  • Amphetamine
  • Conditioned place preference
  • Locomotion
  • Oral stereotypies
  • Reward
  • Ventrolateral striatum

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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