Abstract
Aminoglycosides are a class of small-molecule antibiotics that consist of two or more aminosugars joined by glycosidic linkage to a hexose nucleus. They are clinically useful in treating various infections because of their ability to interfere with protein synthesis in microorganism. However, small molecules possess poor efficacies for delivering nucleic acids to cells, while polymers show increased efficacies. Therefore, there is a need for a library of aminoglycoside polymers. Researchers at the Arizona State University have developed method of using aminoglycoside polymers for binding and delivery of different nucleic acids to cells. In addition to nucleic acids, these aminoglycoside polymers may also be used for aiding and enhancing the delivery of viruses to cells. Cross linking monomeric aminoglycosides results in polymers that demonstrate transgene expression efficacies following plasmid DNA delivery that are much higher than existing standards. The objective of the present invention is to generate more effective and less toxic carrier materials (polymers) for delivery of nucleic acids and viruses. Potential Applications Nucleic acid delivery Nucleic acid binding Benefits and Advantages Significantly higher efficacies Cost effectiveness Simple method of preparation Low immunogenicities Low toxicities Download Original PDF For more information about the inventor(s) and their research, please see Dr. Rege's directory webpage Dr. Rege's laboratory webpage
| Original language | English (US) |
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| State | Published - Sep 29 2011 |