Aminoglycoside based polymers for delivery of nucleic acids and viruses to cells 2

Kaushal Rege (Inventor)

Research output: Patent

Abstract

Aminoglycosides are a class of small-molecule antibiotics that consist of two or more aminosugars joined by glycosidic linkage to a hexose nucleus. They are clinically useful in treating various infections because of their ability to interfere with protein synthesis in microorganism. However, small molecules possess poor efficacies for delivering nucleic acids to cells, while polymers show increased efficacies. Therefore, there is a need for a library of aminoglycoside polymers. Researchers at the Arizona State University have developed method of using aminoglycoside polymers for binding and delivery of different nucleic acids to cells. In addition to nucleic acids, these aminoglycoside polymers may also be used for aiding and enhancing the delivery of viruses to cells. Cross linking monomeric aminoglycosides results in polymers that demonstrate transgene expression efficacies following plasmid DNA delivery that are much higher than existing standards. The objective of the present invention is to generate more effective and less toxic carrier materials (polymers) for delivery of nucleic acids and viruses. Potential Applications Nucleic acid delivery Nucleic acid binding Benefits and Advantages Significantly higher efficacies Cost effectiveness Simple method of preparation Low immunogenicities Low toxicities Download Original PDF For more information about the inventor(s) and their research, please see Dr. Rege's directory webpage Dr. Rege's laboratory webpage
Original languageEnglish (US)
StatePublished - Dec 19 2011

Fingerprint

Aminoglycosides
Viruses
Nucleic Acids
Polymers
Molecules
Hexoses
Poisons
Patents and inventions
Cost effectiveness
Microorganisms
Toxicity
Plasmids
Anti-Bacterial Agents
DNA
Proteins

Cite this

@misc{91ba7cf1be9c4b90b3ec0ded8b8181ea,
title = "Aminoglycoside based polymers for delivery of nucleic acids and viruses to cells 2",
abstract = "Aminoglycosides are a class of small-molecule antibiotics that consist of two or more aminosugars joined by glycosidic linkage to a hexose nucleus. They are clinically useful in treating various infections because of their ability to interfere with protein synthesis in microorganism. However, small molecules possess poor efficacies for delivering nucleic acids to cells, while polymers show increased efficacies. Therefore, there is a need for a library of aminoglycoside polymers. Researchers at the Arizona State University have developed method of using aminoglycoside polymers for binding and delivery of different nucleic acids to cells. In addition to nucleic acids, these aminoglycoside polymers may also be used for aiding and enhancing the delivery of viruses to cells. Cross linking monomeric aminoglycosides results in polymers that demonstrate transgene expression efficacies following plasmid DNA delivery that are much higher than existing standards. The objective of the present invention is to generate more effective and less toxic carrier materials (polymers) for delivery of nucleic acids and viruses. Potential Applications Nucleic acid delivery Nucleic acid binding Benefits and Advantages Significantly higher efficacies Cost effectiveness Simple method of preparation Low immunogenicities Low toxicities Download Original PDF For more information about the inventor(s) and their research, please see Dr. Rege's directory webpage Dr. Rege's laboratory webpage",
author = "Kaushal Rege",
year = "2011",
month = "12",
day = "19",
language = "English (US)",
type = "Patent",

}

TY - PAT

T1 - Aminoglycoside based polymers for delivery of nucleic acids and viruses to cells 2

AU - Rege, Kaushal

PY - 2011/12/19

Y1 - 2011/12/19

N2 - Aminoglycosides are a class of small-molecule antibiotics that consist of two or more aminosugars joined by glycosidic linkage to a hexose nucleus. They are clinically useful in treating various infections because of their ability to interfere with protein synthesis in microorganism. However, small molecules possess poor efficacies for delivering nucleic acids to cells, while polymers show increased efficacies. Therefore, there is a need for a library of aminoglycoside polymers. Researchers at the Arizona State University have developed method of using aminoglycoside polymers for binding and delivery of different nucleic acids to cells. In addition to nucleic acids, these aminoglycoside polymers may also be used for aiding and enhancing the delivery of viruses to cells. Cross linking monomeric aminoglycosides results in polymers that demonstrate transgene expression efficacies following plasmid DNA delivery that are much higher than existing standards. The objective of the present invention is to generate more effective and less toxic carrier materials (polymers) for delivery of nucleic acids and viruses. Potential Applications Nucleic acid delivery Nucleic acid binding Benefits and Advantages Significantly higher efficacies Cost effectiveness Simple method of preparation Low immunogenicities Low toxicities Download Original PDF For more information about the inventor(s) and their research, please see Dr. Rege's directory webpage Dr. Rege's laboratory webpage

AB - Aminoglycosides are a class of small-molecule antibiotics that consist of two or more aminosugars joined by glycosidic linkage to a hexose nucleus. They are clinically useful in treating various infections because of their ability to interfere with protein synthesis in microorganism. However, small molecules possess poor efficacies for delivering nucleic acids to cells, while polymers show increased efficacies. Therefore, there is a need for a library of aminoglycoside polymers. Researchers at the Arizona State University have developed method of using aminoglycoside polymers for binding and delivery of different nucleic acids to cells. In addition to nucleic acids, these aminoglycoside polymers may also be used for aiding and enhancing the delivery of viruses to cells. Cross linking monomeric aminoglycosides results in polymers that demonstrate transgene expression efficacies following plasmid DNA delivery that are much higher than existing standards. The objective of the present invention is to generate more effective and less toxic carrier materials (polymers) for delivery of nucleic acids and viruses. Potential Applications Nucleic acid delivery Nucleic acid binding Benefits and Advantages Significantly higher efficacies Cost effectiveness Simple method of preparation Low immunogenicities Low toxicities Download Original PDF For more information about the inventor(s) and their research, please see Dr. Rege's directory webpage Dr. Rege's laboratory webpage

M3 - Patent

ER -