Aminoacyl-tRNA synthesis in Archaea.

M. Ibba; I. Celic; A. Curnow; H. Kim; J. Pelaschier; D. Tumbula; U. Vothknecht; C. Woese; D. Söll

Aminoacyl-tRNA synthesis in Archaea.

M. Ibba, I. Celic, A. Curnow, H. Kim, J. Pelaschier, D. Tumbula, U. Vothknecht, C. Woese, D. Söll

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanism of aminoacyl-tRNA synthesis differs substantially between Archaea, Bacteria and Eukarya. Sequencing of archaeal genomes has suggested that the asparaginyl-, cysteinyl-, glutaminyl- and lysyl-tRNA synthetases are absent from a number of organisms in this kingdom. The absence of the asparaginyl- and glutaminyl-tRNA synthetases is in agreement with the observation that Asn-tRNA and Gln-tRNA are synthesized by tRNA-dependent transamidation of Asp-tRNA and Glu-tRNA respectively in the archaeon Haloferax volcanii. Biochemical and genetic studies have now shown that while the cysteinyl- and lysyl-tRNA synthetases are present, the enzymes responsible for these activities are unique to Archaea.

Original language	English (US)
Pages (from-to)	305-306
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	37
State	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Aminoacyl-tRNA synthesis in Archaea.",

abstract = "The mechanism of aminoacyl-tRNA synthesis differs substantially between Archaea, Bacteria and Eukarya. Sequencing of archaeal genomes has suggested that the asparaginyl-, cysteinyl-, glutaminyl- and lysyl-tRNA synthetases are absent from a number of organisms in this kingdom. The absence of the asparaginyl- and glutaminyl-tRNA synthetases is in agreement with the observation that Asn-tRNA and Gln-tRNA are synthesized by tRNA-dependent transamidation of Asp-tRNA and Glu-tRNA respectively in the archaeon Haloferax volcanii. Biochemical and genetic studies have now shown that while the cysteinyl- and lysyl-tRNA synthetases are present, the enzymes responsible for these activities are unique to Archaea.",

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T1 - Aminoacyl-tRNA synthesis in Archaea.

AU - Ibba, M.

AU - Celic, I.

AU - Curnow, A.

AU - Kim, H.

AU - Pelaschier, J.

AU - Tumbula, D.

AU - Vothknecht, U.

AU - Woese, C.

AU - Söll, D.

PY - 1997

Y1 - 1997

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AB - The mechanism of aminoacyl-tRNA synthesis differs substantially between Archaea, Bacteria and Eukarya. Sequencing of archaeal genomes has suggested that the asparaginyl-, cysteinyl-, glutaminyl- and lysyl-tRNA synthetases are absent from a number of organisms in this kingdom. The absence of the asparaginyl- and glutaminyl-tRNA synthetases is in agreement with the observation that Asn-tRNA and Gln-tRNA are synthesized by tRNA-dependent transamidation of Asp-tRNA and Glu-tRNA respectively in the archaeon Haloferax volcanii. Biochemical and genetic studies have now shown that while the cysteinyl- and lysyl-tRNA synthetases are present, the enzymes responsible for these activities are unique to Archaea.

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Aminoacyl-tRNA synthesis in Archaea.

Abstract

ASJC Scopus subject areas

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