Aminoacyl-tRNA synthesis in Archaea.

M. Ibba, I. Celic, A. Curnow, H. Kim, J. Pelaschier, D. Tumbula, U. Vothknecht, C. Woese, D. Söll

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Abstract

The mechanism of aminoacyl-tRNA synthesis differs substantially between Archaea, Bacteria and Eukarya. Sequencing of archaeal genomes has suggested that the asparaginyl-, cysteinyl-, glutaminyl- and lysyl-tRNA synthetases are absent from a number of organisms in this kingdom. The absence of the asparaginyl- and glutaminyl-tRNA synthetases is in agreement with the observation that Asn-tRNA and Gln-tRNA are synthesized by tRNA-dependent transamidation of Asp-tRNA and Glu-tRNA respectively in the archaeon Haloferax volcanii. Biochemical and genetic studies have now shown that while the cysteinyl- and lysyl-tRNA synthetases are present, the enzymes responsible for these activities are unique to Archaea.

Original languageEnglish (US)
Pages (from-to)305-306
Number of pages2
JournalNucleic acids symposium series
Issue number37
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Ibba, M., Celic, I., Curnow, A., Kim, H., Pelaschier, J., Tumbula, D., Vothknecht, U., Woese, C., & Söll, D. (1997). Aminoacyl-tRNA synthesis in Archaea. Nucleic acids symposium series, (37), 305-306.