@inproceedings{e66c4ac9d04d42b28de83473a23855b0,
title = "Alzheimer's disease specific markers detected with microfluidic MALDI mass spectrometry (MIMAS)",
abstract = "While soluble amyloid-β (Aβ) oligomeric assemblies are known to be involved in the complex Alzheimer's disease (AD) pathology, their detailed composition and neurotoxicity are still not elucidated. Identification of AD-related A{\ss} species in brain tissue or accessible body fluids would thus provide valuable insight in AD progression. Here, A{\ss} variants from AD patient blood serum are studied using Microfluidics and MALDI Mass Spectrometry (MIMAS). Sample preparation and MALDI analysis are performed in situ to minimize sample loss and improve sensitivity. The MIMAS assay, performed entirely on a microfluidic platform, reveals significantly different signatures between native and serum A{\ss} peptides.",
keywords = "Alzheimer Disease, Amyloid beta, MALDI, Mass Spectrometry, Microfluidics",
author = "Villarreal, {Jorvani Cruz} and Stephanie Williams and Ana Egatz-Gomez and Paul Coleman and Dobrin Nedelkov and Sierks, {Michael R.} and Alexandra Ros",
year = "2020",
month = jan,
day = "1",
language = "English (US)",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "1287--1288",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
}