TY - GEN
T1 - Altered hippocampal morphometry in infants born very preterm
AU - Htite, Elly Dimya
AU - Gajawelli, Niharika
AU - Saint-Martin, Christine
AU - Wei, Miao
AU - Palmis, Sarah
AU - Wang, Yalin
AU - Wintermark, Pia
AU - Deoni, Sean
AU - Lepore, Natasha
AU - Brossard-Racine, Marie
N1 - Funding Information:
This study was collectively funded by the Canadian Institute of Health Research and the Montreal Children's Foundation. At the time of the study, Elly Dimya Htite received studentship support from Healthy Brain Healthy Lives and the Research Institute of the McGill University Health Centre. Dr. Lepore was funded by NIH NIBIB grant R01EB025031 and The Saban Research Institute grant 000013228. Dr. Brossard-Racine received a Canada Research Chair salary award.
Funding Information:
This study was collectively funded by the Canadian Institute of Health Research and the Montreal Children’s Foundation. At the time of the study, Elly Dimya Htite received studentship support from Healthy Brain Healthy Lives and the Research Institute of the McGill University Health Centre. Dr. Lepore was funded by NIH NIBIB grant R01EB025031 and The Saban Research Institute grant 000013228.
Publisher Copyright:
© 2021 SPIE.
PY - 2021
Y1 - 2021
N2 - Preliminary evidence suggests individuals born very-premature have smaller hippocampi on MRI when compared to term-born controls. Moreover, these volumetric reductions have been associated with various cognitive deficits. The hippocampus undergoes an intense period of postnatal volumetric growth during the first year of life. However, this period of development has only been characterized in post-mortem studies. Although volume gain has been previously delineated, changes in hippocampal shape remain undescribed during this unique period. The objective of this study was to characterize and compare morphometric development between very-preterm born infant and healthy controls throughout the first year of life using multivariate tensor-based morphometry (mTBM). We segmented left and right hippocampi from 133 T1-weighted images acquired from 20 very-preterm infants and 67 term-born controls between atbirth or term-equivalent age and 12 months of age. MRI were performed on a 3 Tesla scanner at 3-month intervals (i.e., term-equivalence, 3, 6, 9, 12 months). We used mTBM to compare shape between groups at each time-point. We found that subregions of the hippocampus including the dentate gyrus, CA2, CA3 and subiculum were morphometrically different, especially at term-equivalence age. Morphometric differences were less prominent at 3 and 6 months but reappeared at 9 and 12 months, particularly in the left hippocampus. Although hippocampal shape differences between very-preterm and healthy term-born infants seem to decrease during the first 6 months of life, atypical shape development reappeared at 9-12 months which likely highlights altered periods of morphologic development. Future long-term studies will inform if these developmental differences continue to increase or disappear in subsequent years.
AB - Preliminary evidence suggests individuals born very-premature have smaller hippocampi on MRI when compared to term-born controls. Moreover, these volumetric reductions have been associated with various cognitive deficits. The hippocampus undergoes an intense period of postnatal volumetric growth during the first year of life. However, this period of development has only been characterized in post-mortem studies. Although volume gain has been previously delineated, changes in hippocampal shape remain undescribed during this unique period. The objective of this study was to characterize and compare morphometric development between very-preterm born infant and healthy controls throughout the first year of life using multivariate tensor-based morphometry (mTBM). We segmented left and right hippocampi from 133 T1-weighted images acquired from 20 very-preterm infants and 67 term-born controls between atbirth or term-equivalent age and 12 months of age. MRI were performed on a 3 Tesla scanner at 3-month intervals (i.e., term-equivalence, 3, 6, 9, 12 months). We used mTBM to compare shape between groups at each time-point. We found that subregions of the hippocampus including the dentate gyrus, CA2, CA3 and subiculum were morphometrically different, especially at term-equivalence age. Morphometric differences were less prominent at 3 and 6 months but reappeared at 9 and 12 months, particularly in the left hippocampus. Although hippocampal shape differences between very-preterm and healthy term-born infants seem to decrease during the first 6 months of life, atypical shape development reappeared at 9-12 months which likely highlights altered periods of morphologic development. Future long-term studies will inform if these developmental differences continue to increase or disappear in subsequent years.
KW - Hippocampus
KW - MRI
KW - MTBM
KW - Morphometry
KW - Neonates
KW - Preterm
UR - http://www.scopus.com/inward/record.url?scp=85123054340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123054340&partnerID=8YFLogxK
U2 - 10.1117/12.2606249
DO - 10.1117/12.2606249
M3 - Conference contribution
AN - SCOPUS:85123054340
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - 17th International Symposium on Medical Information Processing and Analysis
A2 - Romero, Eduardo
A2 - Costa, Eduardo Tavares
A2 - Brieva, Jorge
A2 - Rittner, Leticia
A2 - Linguraru, Marius George
A2 - Lepore, Natasha
PB - SPIE
T2 - 17th International Symposium on Medical Information Processing and Analysis
Y2 - 17 November 2021 through 19 November 2021
ER -