Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

Medicine & Life Sciences

• Type I DNA Topoisomerase 100%
• Ligation 67%
• DNA 42%
• Oligonucleotides 39%
• Enzymes 36%
• DNA Cleavage 12%
• Nucleic Acids 9%
• Suicide 8%
• Tyrosine 8%

Chemical Compounds

• Oligonucleotide 67%
• Cleavage 39%
• Nucleic Acid Structure 27%
• Chemical Depolymerization 22%
• Modification 21%
• Methylene Group 20%
• Tyrosine 17%
• Homogeneity 16%
• Nucleophile 16%
• Displacement 15%
• Chemical Transformation 12%
• pH Value 8%

Engineering & Materials Science

• DNA 79%
• Enzymes 43%
• Oligonucleotides 32%
• Substrates 15%
• Nucleophiles 11%
• Nucleic acids 8%
• Assays 6%
• Degradation 3%