Alpha-synuclein propagation: New insights from animal models

Benjamin Dehay, Miquel Vila, Erwan Bezard, Patrik Brundin, Jeffrey H. Kordower

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations

Abstract

Aggregation of alpha-synuclein is implicated in several neurodegenerative diseases collectively termed synucleinopathies. Emerging evidence strongly implicates cell-to-cell transmission of misfolded alpha-synuclein as a common pathogenetic mechanism in synucleinopathies. The impact of alpha-synuclein pathology on neuronal dysfunction and behavioral impairments is being explored in animal models. This review provides an update on how research in animal models supports the concept that misfolded alpha-synuclein spreads from cell to cell and describes how findings in animal models might relate to the disease process in humans. Finally, we discuss the current underlying molecular and cellular mechanisms and future therapeutic strategies targeting alpha-synuclein propagation.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalMovement Disorders
Volume31
Issue number2
DOIs
StatePublished - Feb 2016
Externally publishedYes

Keywords

  • alpha-synuclein
  • animal models
  • Parkinson's disease
  • propagation
  • synucleinopathy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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