Alpha-synuclein propagation: New insights from animal models

Benjamin Dehay; Miquel Vila; Erwan Bezard; Patrik Brundin; Jeffrey H. Kordower

doi:10.1002/mds.26370

Alpha-synuclein propagation: New insights from animal models

Benjamin Dehay, Miquel Vila, Erwan Bezard, Patrik Brundin, Jeffrey H. Kordower

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

Aggregation of alpha-synuclein is implicated in several neurodegenerative diseases collectively termed synucleinopathies. Emerging evidence strongly implicates cell-to-cell transmission of misfolded alpha-synuclein as a common pathogenetic mechanism in synucleinopathies. The impact of alpha-synuclein pathology on neuronal dysfunction and behavioral impairments is being explored in animal models. This review provides an update on how research in animal models supports the concept that misfolded alpha-synuclein spreads from cell to cell and describes how findings in animal models might relate to the disease process in humans. Finally, we discuss the current underlying molecular and cellular mechanisms and future therapeutic strategies targeting alpha-synuclein propagation.

Original language	English (US)
Pages (from-to)	161-168
Number of pages	8
Journal	Movement Disorders
Volume	31
Issue number	2
DOIs	https://doi.org/10.1002/mds.26370
State	Published - Feb 2016
Externally published	Yes

Keywords

Parkinson's disease
alpha-synuclein
animal models
propagation
synucleinopathy

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.26370

Cite this

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title = "Alpha-synuclein propagation: New insights from animal models",

abstract = "Aggregation of alpha-synuclein is implicated in several neurodegenerative diseases collectively termed synucleinopathies. Emerging evidence strongly implicates cell-to-cell transmission of misfolded alpha-synuclein as a common pathogenetic mechanism in synucleinopathies. The impact of alpha-synuclein pathology on neuronal dysfunction and behavioral impairments is being explored in animal models. This review provides an update on how research in animal models supports the concept that misfolded alpha-synuclein spreads from cell to cell and describes how findings in animal models might relate to the disease process in humans. Finally, we discuss the current underlying molecular and cellular mechanisms and future therapeutic strategies targeting alpha-synuclein propagation.",

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author = "Benjamin Dehay and Miquel Vila and Erwan Bezard and Patrik Brundin and Kordower, {Jeffrey H.}",

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AU - Bezard, Erwan

AU - Brundin, Patrik

AU - Kordower, Jeffrey H.

N1 - Funding Information: Our apologies to many authors whose work could not be cited in this review because of space limitations. Publisher Copyright: © 2015 International Parkinson and Movement Disorder Society

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AB - Aggregation of alpha-synuclein is implicated in several neurodegenerative diseases collectively termed synucleinopathies. Emerging evidence strongly implicates cell-to-cell transmission of misfolded alpha-synuclein as a common pathogenetic mechanism in synucleinopathies. The impact of alpha-synuclein pathology on neuronal dysfunction and behavioral impairments is being explored in animal models. This review provides an update on how research in animal models supports the concept that misfolded alpha-synuclein spreads from cell to cell and describes how findings in animal models might relate to the disease process in humans. Finally, we discuss the current underlying molecular and cellular mechanisms and future therapeutic strategies targeting alpha-synuclein propagation.

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Alpha-synuclein propagation: New insights from animal models

Abstract

Keywords

ASJC Scopus subject areas

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