Allograft loss in renal transplant recipients with Fabry's disease activated protein C resistance

Gary S. Friedman, Daniel Wik, Linda Silva, J. C. Abdou, H. U. Meier-Kriesche, Bruce Kaplan, Luigi Bonomini, Penny DeFranco, Neil Lyman, Shamkant Mulgaonkar, Martin Jacobs

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations

    Abstract

    Introduction. Fabry's disease is associated with an increased incidence of thrombotic events and rejection. Spontaneous thrombosis of a functioning cadaveric renal allograft in a recipient with Fabry's disease prompted prospective evaluation of all transplant candidates with Fabry's disease for hypercoagulability. Materials and Methods. Transplant candidates with Fabry's disease were tested for hypercoagulability, analyzed for HLA-type and ABO group, and comorbid conditions suggestive of hypercoagulability. Results. A unique association of Fabry's disease with activated protein C Resistance was documented in a cohort of Caucasian male renal transplant recipients with Fabry's disease. Four of five patients were blood group A and had no significant comorbid conditions suggestive of hypercoagulability. The resistance to activation of protein C (APCR)(+) patients shared HLA loci-B8 and Dr3, although the APCR(-) patients shared loci-B27 and -B38. Conclusions. Due to the observed increase in the incidence of APCR in our Fabry's cohort, we suggest screening all patients with Fabry's disease for APCR. Because factor V and factor Va receptors are found on vascular endothelium and peripheral blood monocytes, APCR in the presence of Fabry's disease may be a nonimmunological stimulus for rejection. Analysis of typing in patients with Fabry's disease may further elucidate HLA-based association of Fabry's disease and resistance to activated protein C with the risk of thrombosis and rejection.

    Original languageEnglish (US)
    Pages (from-to)2099-2102
    Number of pages4
    JournalTransplantation
    Volume69
    Issue number10
    DOIs
    StatePublished - May 27 2000

    ASJC Scopus subject areas

    • Transplantation

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