TY - JOUR
T1 - Alcohol Misuse Across the Life Span
T2 - Insights From Developmental Studies in Behavior Genetics
AU - Savage, Jeanne E.
AU - Long, Elizabeth C.
AU - Kuo, Sally I.Chun
AU - Cooke, Megan E.
AU - Su, Jinni
AU - Barr, Peter B.
AU - Salvatore, Jessica E.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors of this work were supported by grants F31AA024378 (Savage), F31AA024380 (Cooke), K01AA024152 (Salvatore) from the National Institute on Alcohol Abuse and Alcoholism. The funding agencies had no further role in the preparation of this work or the decision to submit the manuscript for publication, and the content does not necessarily reflect the official views of these organizations.
Publisher Copyright:
© The Author(s) 2017.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Alcohol misuse, one of today’s greatest public health challenges, is a developmentally dynamic, complex behavior at the intersection of genetic and environmental influences. This review examines such influences from a behavior genetics perspective and discusses implications for public policy. Alcohol misuse is moderately heritable with genetic influences accounting for around 50% of its variance, but to date, few specific genes have been identified. However, numerous environmental and social factors moderate genetic risk, including parents, peers, romantic partners, family dynamics, employment, laws, and cultural influences. These moderating factors change in salience across development, and accordingly, no one-size-fits-all approach is suitable for reducing alcohol misuse at a large scale. We provide examples of some effective prevention and intervention programs and discuss a framework for using the behavior genetics evidence to inform future public policy efforts.
AB - Alcohol misuse, one of today’s greatest public health challenges, is a developmentally dynamic, complex behavior at the intersection of genetic and environmental influences. This review examines such influences from a behavior genetics perspective and discusses implications for public policy. Alcohol misuse is moderately heritable with genetic influences accounting for around 50% of its variance, but to date, few specific genes have been identified. However, numerous environmental and social factors moderate genetic risk, including parents, peers, romantic partners, family dynamics, employment, laws, and cultural influences. These moderating factors change in salience across development, and accordingly, no one-size-fits-all approach is suitable for reducing alcohol misuse at a large scale. We provide examples of some effective prevention and intervention programs and discuss a framework for using the behavior genetics evidence to inform future public policy efforts.
KW - alcohol misuse
KW - alcohol use disorder
KW - behavior genetics
KW - development
KW - public policy
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U2 - 10.1177/2372732217720222
DO - 10.1177/2372732217720222
M3 - Review article
AN - SCOPUS:85056758530
SN - 2372-7322
VL - 4
SP - 186
EP - 193
JO - Policy Insights from the Behavioral and Brain Sciences
JF - Policy Insights from the Behavioral and Brain Sciences
IS - 2
ER -