Alcohol actions on GABAA receptors: From protein structure to mouse behavior

S. Ueno, R. A. Harris, R. O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, M. F. Olive, K. J. Buck, H. M. Hood, Y. Blednov, G. Findlay, M. P. Mascia

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cε-regulated sensitivity of γ-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor γ2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Karl J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia.

Original languageEnglish (US)
Pages (from-to)76S-81S
JournalAlcoholism: Clinical and Experimental Research
Volume25
Issue number5 SUPPL.
DOIs
StatePublished - 2001

Keywords

  • Alcohol Withdrawal
  • GABA
  • Glycine Receptors
  • Protein Kinase C
  • Quantitative Trait Locus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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    Ueno, S., Harris, R. A., Messing, R. O., Sanchez-Perez, A. M., Hodge, C. W., McMahon, T., Wang, D., Mehmert, K. K., Kelley, S. P., Haywood, A., Olive, M. F., Buck, K. J., Hood, H. M., Blednov, Y., Findlay, G., & Mascia, M. P. (2001). Alcohol actions on GABAA receptors: From protein structure to mouse behavior. Alcoholism: Clinical and Experimental Research, 25(5 SUPPL.), 76S-81S. https://doi.org/10.1111/j.1530-0277.2001.tb02378.x