Aging and its modulation in a long-lived worker caste of the honey bee

Daniel Münch, Claus D. Kreibich, Gro Amdam

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Highly social animals provide alternative aging models in which vastly different lifespan patterns are flexible, and linked to social caste. Research in these species aims to reveal how environment, including social cues, can shape the transition between shortlived and extremely long-lived phenotypes with negligible senescence. Among honey bee workers, short to intermediate lifespans are typical for summer castes, while the winter caste can live up to 10 times longer. For summer castes, experimental interventions could predictably accelerate, slow or revert functional senescence. In contrast, little is known about the particular conditions under which periods of negligible senescence in winter castes can be disrupted or sustained. We asked how manipulation of social environment in colonies with long-lived winter bees might alter the pace of functional senescence, measured as learning performance, as well as of cellular senescence, measured as lipofuscin accumulation. We show that behavioral senescence becomes rapidly detectable when the winter state is disrupted, and changes in social task behaviors and social environment (brood) are induced. Likewise, we found that cellular senescence was induced by such social intervention. However, cellular senescence showed marked regional differences, suggesting that particular brain regions age slower than others. Finally, by preventing post-winter colonies from brood rearing, behavioral senescence became undetectable, even after transition to the usually short-lived phenotypes had occurred. We envision that social regulation of negligible functional senescence and highly dynamic accumulation of a universal symptom of cellular aging (lipofuscin) offers rewarding perspectives to target proximate mechanisms of slowed aging.

Original languageEnglish (US)
Pages (from-to)1638-1649
Number of pages12
JournalJournal of Experimental Biology
Volume216
Issue number9
DOIs
StatePublished - May 2013

Fingerprint

worker caste
Honey
Bees
honey
senescence
Social Class
bee
honey bees
social environment
Cell Aging
caste
winter
Social Environment
Lipofuscin
phenotype
worker honey bees
brood rearing
summer
social behavior
Phenotype

Keywords

  • Brain
  • Learning
  • Lipofuscin
  • Senescence

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Physiology
  • Insect Science
  • Aquatic Science

Cite this

Aging and its modulation in a long-lived worker caste of the honey bee. / Münch, Daniel; Kreibich, Claus D.; Amdam, Gro.

In: Journal of Experimental Biology, Vol. 216, No. 9, 05.2013, p. 1638-1649.

Research output: Contribution to journalArticle

Münch, Daniel ; Kreibich, Claus D. ; Amdam, Gro. / Aging and its modulation in a long-lived worker caste of the honey bee. In: Journal of Experimental Biology. 2013 ; Vol. 216, No. 9. pp. 1638-1649.
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