TY - JOUR
T1 - Ageing as a primary risk factor for Parkinson's disease
T2 - Evidence from studies of non-human primates
AU - Collier, Timothy J.
AU - Kanaan, Nicholas M.
AU - Kordower, Jeffrey H.
PY - 2011/6
Y1 - 2011/6
N2 - Ageing is the greatest risk factor for the development of Parkinson's disease. However, the current dogma holds that cellular mechanisms that are associated with ageing of midbrain dopamine neurons and those that are related to dopamine neuron degeneration in Parkinson's disease are unrelated. We propose, based on evidence from studies of non-human primates, that normal ageing and the degeneration of dopamine neurons in Parkinson's disease are linked by the same cellular mechanisms and, therefore, that markers of cellular risk factors accumulate with age in a pattern that mimics the pattern of degeneration observed in Parkinson's disease. We contend that ageing induces a pre-parkinsonian state, and that the cellular mechanisms of dopamine neuron demise during normal ageing are accelerated or exaggerated in Parkinson's disease through a combination of genetic and environmental factors.
AB - Ageing is the greatest risk factor for the development of Parkinson's disease. However, the current dogma holds that cellular mechanisms that are associated with ageing of midbrain dopamine neurons and those that are related to dopamine neuron degeneration in Parkinson's disease are unrelated. We propose, based on evidence from studies of non-human primates, that normal ageing and the degeneration of dopamine neurons in Parkinson's disease are linked by the same cellular mechanisms and, therefore, that markers of cellular risk factors accumulate with age in a pattern that mimics the pattern of degeneration observed in Parkinson's disease. We contend that ageing induces a pre-parkinsonian state, and that the cellular mechanisms of dopamine neuron demise during normal ageing are accelerated or exaggerated in Parkinson's disease through a combination of genetic and environmental factors.
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U2 - 10.1038/nrn3039
DO - 10.1038/nrn3039
M3 - Review article
C2 - 21587290
AN - SCOPUS:79957467314
SN - 1471-003X
VL - 12
SP - 359
EP - 366
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 6
ER -