Age-structured and delay differential-difference model of hematopoietic stem cell dynamics

Mostafa Adimy, Abdennasser Chekroun, Tarik Mohamed Touaoula, Yang Kuang

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In this paper, we investigate a mathematical model of hematopoietic stem cell dynamics. We take two cell populations into account, quiescent and proliferating one, and we note the difference between dividing cells that enter directly to the quiescent phase and dividing cells that return to the proliferating phase to divide again. The resulting mathematical model is a system of two age-structured partial differential equations. By integrating this system over age and using the characteristics method, we reduce it to a delay differential-difference system, and we investigate the existence and stability of the steady states. We give sufficient conditions for boundedness and unbound-edness properties for the solutions of this system. By constructing a Lyapunov function, the trivial steady state, describing cell's dying out, is proven to be globally asymptotically stable when it is the only equilibrium. The stability analysis of the unique positive steady state, the most biologically meaningful one, and the existence of a Hopf bifurcation allow the determination of a stability area, which is related to a delay-dependent characteristic equation. Numerical simulations illustrate our results on the asymptotic behavior of the steady states and show very rich dynamics of this model. This study may be helpful in understanding the uncontrolled proliferation of blood cells in some hematological disorders.

Original languageEnglish (US)
Pages (from-to)2765-2791
Number of pages27
JournalDiscrete and Continuous Dynamical Systems - Series B
Volume20
Issue number9
DOIs
StatePublished - Nov 1 2015

Keywords

  • Age-structured partial differential equations
  • Cell dynamic
  • Delay differential-difference system
  • Hematopoietic stem cells
  • Hopf bifurcation
  • Lyapunov function
  • Stability switch

ASJC Scopus subject areas

  • Discrete Mathematics and Combinatorics
  • Applied Mathematics

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