Age-related dendritic growth in dentate gyrus of human brain is followed by regression in the 'oldest old'

Dorothy G. Flood, Stephen J. Buell, Charles H. Defiore, Gary J. Horwitz, Paul D. Coleman

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

Dendritic extent in dentate gyrus granule cells of normal aging human brain was found to increase between middle age (fifties) and early old age (seventies). However, dendritic regression was found in the oldest old (nineties). This finding of dendritic regression following growth is in contrast to previous quantitative reports of continued dendritic growth in parahippocampal gyrus of aging human brain. This new result reinforces the concept of age and region specificity in changes in dendritic extent.

Original languageEnglish (US)
Pages (from-to)366-368
Number of pages3
JournalBrain Research
Volume345
Issue number2
DOIs
StatePublished - Oct 21 1985
Externally publishedYes

Keywords

  • aging
  • dendrite
  • dentate gyrus
  • hippocampus
  • human

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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