Age-related alterations in GABAA receptor subunits in the nonhuman primate hippocampus

Robert A. Rissman, Romy Nocera, Laura M. Fuller, Jeffrey H. Kordower, David M. Armstrong

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Pharmacological studies have documented that altered drug responses, particularly to benzodiazepines, are common in elderly populations. While numerous factors may contribute to changes in drug response, age-related alterations in the molecular composition of GABAA receptors may be a key factor in regulating these responses. We employed quantitative densitometry to examine the cytological features and density of highly prevalent hippocampal GABAA receptor subunits (α1 and β2/3) in young and aged rhesus monkeys. α1 and β2/3 subunit immunostaining was differentially distributed throughout the hippocampus. In addition, β2/3 immunolabeling in aged monkeys was characterized by marked intersubject variability in labeling intensity, with dramatic reductions present in 3 of 5 samples. α1 immunolabeling in aged monkeys was significantly reduced in the CA2 and CA3 subregions, and in hilus/polymorphic layer of the dentate gyrus. Collectively, our findings demonstrate that not only are GABAA receptor subunits differentially distributed throughout the hippocampus, but they are also differentially altered with increased age-changes that may have an important impact on the binding properties of GABAA receptor pharmacological agents.

Original languageEnglish (US)
Pages (from-to)120-130
Number of pages11
JournalBrain Research
Volume1073-1074
Issue number1
DOIs
StatePublished - Feb 16 2006
Externally publishedYes

Keywords

  • Aging
  • Benzodiazepine
  • Densitometry
  • GABA receptor subunit
  • Hippocampus
  • Immunohistochemistry
  • Nonhuman primate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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