Advancing translational research with next-generation protein microarrays

Xiaobo Yu, Brianne Petritis, Joshua LaBaer

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Protein microarrays are a high-throughput technology used increasingly in translational research, seeking to apply basic science findings to enhance human health. In addition to assessing protein levels, posttranslational modifications, and signaling pathways in patient samples, protein microarrays have aided in the identification of potential protein biomarkers of disease and infection. In this perspective, the different types of full-length protein microarrays that are used in translational research are reviewed. Specific studies employing these microarrays are presented to highlight their potential in finding solutions to real clinical problems. Finally, the criteria that should be considered when developing next-generation protein microarrays are provided.

Original languageEnglish (US)
Pages (from-to)1238-1250
Number of pages13
JournalProteomics
Volume16
Issue number8
DOIs
StatePublished - Apr 1 2016

Keywords

  • Biomarker
  • In vitro diagnostics
  • Protein microarray
  • Translational research

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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