Advancing alternatives analysis

The role of predictive toxicology in selecting safer chemical products and processes

Timothy Malloy, Virginia Zaunbrecher, Elizabeth Beryt, Richard Judson, Raymond Tice, Patrick Allard, Ann Blake, Ila Cote, Hilary Godwin, Lauren Heine, Patrick Kerzic, Jakub Kostal, Gary Marchant, Jennifer McPartland, Kelly Moran, Andre Nel, Oladele Ogunseitan, Mark Rossi, Kristina Thayer, Joel Tickner & 2 others Margaret Whittaker, Ken Zarker

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in a more cost-effective manner than traditional approaches. The present article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents 4 recommendations for its advancement. It recommends using case studies to advance the integration of predictive toxicology into AA, adopting a stepwise process to employing predictive toxicology in AA beginning with prioritization of chemicals of concern, leveraging existing resources to advance the integration of predictive toxicology into the practice of AA, and supporting transdisciplinary efforts. The further incorporation of predictive toxicology into AA would advance the ability of companies and regulators to select alternatives to harmful ingredients, and potentially increase the use of predictive toxicology in regulation more broadly. Integr Environ Assess Manag 2017;13:915–925.

Original languageEnglish (US)
Pages (from-to)915-925
Number of pages11
JournalIntegrated Environmental Assessment and Management
Volume13
Issue number5
DOIs
StatePublished - Sep 1 2017

Fingerprint

toxicology
chemical process
regulation
prioritization
chemical product
analysis
transdisciplinary
product design
viability
safety
resource
cost
ability
costs
resources

Keywords

  • Alternative testing strategies
  • Alternatives analysis
  • Alternatives assessment
  • Predictive toxicology
  • Regulation

ASJC Scopus subject areas

  • Geography, Planning and Development
  • Environmental Science(all)

Cite this

Advancing alternatives analysis : The role of predictive toxicology in selecting safer chemical products and processes. / Malloy, Timothy; Zaunbrecher, Virginia; Beryt, Elizabeth; Judson, Richard; Tice, Raymond; Allard, Patrick; Blake, Ann; Cote, Ila; Godwin, Hilary; Heine, Lauren; Kerzic, Patrick; Kostal, Jakub; Marchant, Gary; McPartland, Jennifer; Moran, Kelly; Nel, Andre; Ogunseitan, Oladele; Rossi, Mark; Thayer, Kristina; Tickner, Joel; Whittaker, Margaret; Zarker, Ken.

In: Integrated Environmental Assessment and Management, Vol. 13, No. 5, 01.09.2017, p. 915-925.

Research output: Contribution to journalArticle

Malloy, T, Zaunbrecher, V, Beryt, E, Judson, R, Tice, R, Allard, P, Blake, A, Cote, I, Godwin, H, Heine, L, Kerzic, P, Kostal, J, Marchant, G, McPartland, J, Moran, K, Nel, A, Ogunseitan, O, Rossi, M, Thayer, K, Tickner, J, Whittaker, M & Zarker, K 2017, 'Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes', Integrated Environmental Assessment and Management, vol. 13, no. 5, pp. 915-925. https://doi.org/10.1002/ieam.1923
Malloy, Timothy ; Zaunbrecher, Virginia ; Beryt, Elizabeth ; Judson, Richard ; Tice, Raymond ; Allard, Patrick ; Blake, Ann ; Cote, Ila ; Godwin, Hilary ; Heine, Lauren ; Kerzic, Patrick ; Kostal, Jakub ; Marchant, Gary ; McPartland, Jennifer ; Moran, Kelly ; Nel, Andre ; Ogunseitan, Oladele ; Rossi, Mark ; Thayer, Kristina ; Tickner, Joel ; Whittaker, Margaret ; Zarker, Ken. / Advancing alternatives analysis : The role of predictive toxicology in selecting safer chemical products and processes. In: Integrated Environmental Assessment and Management. 2017 ; Vol. 13, No. 5. pp. 915-925.
@article{baef9209287942e0819bcdd8d8cf7cca,
title = "Advancing alternatives analysis: The role of predictive toxicology in selecting safer chemical products and processes",
abstract = "Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in a more cost-effective manner than traditional approaches. The present article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents 4 recommendations for its advancement. It recommends using case studies to advance the integration of predictive toxicology into AA, adopting a stepwise process to employing predictive toxicology in AA beginning with prioritization of chemicals of concern, leveraging existing resources to advance the integration of predictive toxicology into the practice of AA, and supporting transdisciplinary efforts. The further incorporation of predictive toxicology into AA would advance the ability of companies and regulators to select alternatives to harmful ingredients, and potentially increase the use of predictive toxicology in regulation more broadly. Integr Environ Assess Manag 2017;13:915–925.",
keywords = "Alternative testing strategies, Alternatives analysis, Alternatives assessment, Predictive toxicology, Regulation",
author = "Timothy Malloy and Virginia Zaunbrecher and Elizabeth Beryt and Richard Judson and Raymond Tice and Patrick Allard and Ann Blake and Ila Cote and Hilary Godwin and Lauren Heine and Patrick Kerzic and Jakub Kostal and Gary Marchant and Jennifer McPartland and Kelly Moran and Andre Nel and Oladele Ogunseitan and Mark Rossi and Kristina Thayer and Joel Tickner and Margaret Whittaker and Ken Zarker",
year = "2017",
month = "9",
day = "1",
doi = "10.1002/ieam.1923",
language = "English (US)",
volume = "13",
pages = "915--925",
journal = "Integrated Environmental Assessment and Management",
issn = "1551-3793",
publisher = "SETAC Press",
number = "5",

}

TY - JOUR

T1 - Advancing alternatives analysis

T2 - The role of predictive toxicology in selecting safer chemical products and processes

AU - Malloy, Timothy

AU - Zaunbrecher, Virginia

AU - Beryt, Elizabeth

AU - Judson, Richard

AU - Tice, Raymond

AU - Allard, Patrick

AU - Blake, Ann

AU - Cote, Ila

AU - Godwin, Hilary

AU - Heine, Lauren

AU - Kerzic, Patrick

AU - Kostal, Jakub

AU - Marchant, Gary

AU - McPartland, Jennifer

AU - Moran, Kelly

AU - Nel, Andre

AU - Ogunseitan, Oladele

AU - Rossi, Mark

AU - Thayer, Kristina

AU - Tickner, Joel

AU - Whittaker, Margaret

AU - Zarker, Ken

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in a more cost-effective manner than traditional approaches. The present article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents 4 recommendations for its advancement. It recommends using case studies to advance the integration of predictive toxicology into AA, adopting a stepwise process to employing predictive toxicology in AA beginning with prioritization of chemicals of concern, leveraging existing resources to advance the integration of predictive toxicology into the practice of AA, and supporting transdisciplinary efforts. The further incorporation of predictive toxicology into AA would advance the ability of companies and regulators to select alternatives to harmful ingredients, and potentially increase the use of predictive toxicology in regulation more broadly. Integr Environ Assess Manag 2017;13:915–925.

AB - Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in a more cost-effective manner than traditional approaches. The present article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents 4 recommendations for its advancement. It recommends using case studies to advance the integration of predictive toxicology into AA, adopting a stepwise process to employing predictive toxicology in AA beginning with prioritization of chemicals of concern, leveraging existing resources to advance the integration of predictive toxicology into the practice of AA, and supporting transdisciplinary efforts. The further incorporation of predictive toxicology into AA would advance the ability of companies and regulators to select alternatives to harmful ingredients, and potentially increase the use of predictive toxicology in regulation more broadly. Integr Environ Assess Manag 2017;13:915–925.

KW - Alternative testing strategies

KW - Alternatives analysis

KW - Alternatives assessment

KW - Predictive toxicology

KW - Regulation

UR - http://www.scopus.com/inward/record.url?scp=85019945050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019945050&partnerID=8YFLogxK

U2 - 10.1002/ieam.1923

DO - 10.1002/ieam.1923

M3 - Article

VL - 13

SP - 915

EP - 925

JO - Integrated Environmental Assessment and Management

JF - Integrated Environmental Assessment and Management

SN - 1551-3793

IS - 5

ER -