Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics

Emily A. Higgins Keppler, Carrie L. Jenkins, Trenton J. Davis, Heather Bean

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

Original languageEnglish (US)
Pages (from-to)275-286
Number of pages12
JournalTrAC - Trends in Analytical Chemistry
Volume109
DOIs
StatePublished - Dec 1 2018

Keywords

  • Animal models
  • Biospecimens
  • Biotransformation
  • Comprehensive two-dimensional gas chromatography (GC × GC)
  • Data reporting
  • In vitro analyses
  • Metabolomics
  • Multitrophic interactions
  • Sampling

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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