Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics

Emily A. Higgins Keppler, Carrie L. Jenkins, Trenton J. Davis, Heather Bean

    Research output: Contribution to journalReview article

    Abstract

    Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

    Original languageEnglish (US)
    Pages (from-to)275-286
    Number of pages12
    JournalTrAC - Trends in Analytical Chemistry
    Volume109
    DOIs
    StatePublished - Dec 1 2018

    Fingerprint

    Gas chromatography
    Complex Mixtures
    Sampling
    Metabolomics

    Keywords

    • Animal models
    • Biospecimens
    • Biotransformation
    • Comprehensive two-dimensional gas chromatography (GC × GC)
    • Data reporting
    • In vitro analyses
    • Metabolomics
    • Multitrophic interactions
    • Sampling

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Spectroscopy

    Cite this

    Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics. / Higgins Keppler, Emily A.; Jenkins, Carrie L.; Davis, Trenton J.; Bean, Heather.

    In: TrAC - Trends in Analytical Chemistry, Vol. 109, 01.12.2018, p. 275-286.

    Research output: Contribution to journalReview article

    Higgins Keppler, Emily A. ; Jenkins, Carrie L. ; Davis, Trenton J. ; Bean, Heather. / Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics. In: TrAC - Trends in Analytical Chemistry. 2018 ; Vol. 109. pp. 275-286.
    @article{b5d940ae37de4aa392b90b446be35c7f,
    title = "Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics",
    abstract = "Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.",
    keywords = "Animal models, Biospecimens, Biotransformation, Comprehensive two-dimensional gas chromatography (GC × GC), Data reporting, In vitro analyses, Metabolomics, Multitrophic interactions, Sampling",
    author = "{Higgins Keppler}, {Emily A.} and Jenkins, {Carrie L.} and Davis, {Trenton J.} and Heather Bean",
    year = "2018",
    month = "12",
    day = "1",
    doi = "10.1016/j.trac.2018.10.015",
    language = "English (US)",
    volume = "109",
    pages = "275--286",
    journal = "TrAC - Trends in Analytical Chemistry",
    issn = "0165-9936",
    publisher = "Elsevier",

    }

    TY - JOUR

    T1 - Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics

    AU - Higgins Keppler, Emily A.

    AU - Jenkins, Carrie L.

    AU - Davis, Trenton J.

    AU - Bean, Heather

    PY - 2018/12/1

    Y1 - 2018/12/1

    N2 - Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

    AB - Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

    KW - Animal models

    KW - Biospecimens

    KW - Biotransformation

    KW - Comprehensive two-dimensional gas chromatography (GC × GC)

    KW - Data reporting

    KW - In vitro analyses

    KW - Metabolomics

    KW - Multitrophic interactions

    KW - Sampling

    UR - http://www.scopus.com/inward/record.url?scp=85056147901&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85056147901&partnerID=8YFLogxK

    U2 - 10.1016/j.trac.2018.10.015

    DO - 10.1016/j.trac.2018.10.015

    M3 - Review article

    VL - 109

    SP - 275

    EP - 286

    JO - TrAC - Trends in Analytical Chemistry

    JF - TrAC - Trends in Analytical Chemistry

    SN - 0165-9936

    ER -