Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics

Emily A. Higgins Keppler; Carrie L. Jenkins; Trenton J. Davis; Heather Bean

doi:10.1016/j.trac.2018.10.015

Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics

Emily A. Higgins Keppler, Carrie L. Jenkins, Trenton J. Davis, Heather Bean

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Abstract

Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

Original language	English (US)
Pages (from-to)	275-286
Number of pages	12
Journal	TrAC - Trends in Analytical Chemistry
Volume	109
DOIs	https://doi.org/10.1016/j.trac.2018.10.015
State	Published - Dec 2018

Keywords

Animal models
Biospecimens
Biotransformation
Comprehensive two-dimensional gas chromatography (GC × GC)
Data reporting
In vitro analyses
Metabolomics
Multitrophic interactions
Sampling

ASJC Scopus subject areas

Analytical Chemistry
Spectroscopy

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10.1016/j.trac.2018.10.015

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title = "Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics",

abstract = "Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.",

keywords = "Animal models, Biospecimens, Biotransformation, Comprehensive two-dimensional gas chromatography (GC × GC), Data reporting, In vitro analyses, Metabolomics, Multitrophic interactions, Sampling",

author = "{Higgins Keppler}, {Emily A.} and Jenkins, {Carrie L.} and Davis, {Trenton J.} and Heather Bean",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2018",

month = dec,

doi = "10.1016/j.trac.2018.10.015",

language = "English (US)",

volume = "109",

pages = "275--286",

journal = "TrAC - Trends in Analytical Chemistry",

issn = "0165-9936",

publisher = "Elsevier",

}

TY - JOUR

T1 - Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics

AU - Higgins Keppler, Emily A.

AU - Jenkins, Carrie L.

AU - Davis, Trenton J.

AU - Bean, Heather

PY - 2018/12

Y1 - 2018/12

N2 - Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

AB - Due to excellent separation capacity for complex mixtures of chemicals, comprehensive two-dimensional gas chromatography (GC × GC) is being utilized with increasing frequency for metabolomics analyses. This review describes recent advances in GC × GC method development for metabolomics, organismal sampling techniques compatible with GC × GC, metabolomic discoveries made using GC × GC, and recommendations and best practices for collecting and reporting GC × GC metabolomics data.

KW - Animal models

KW - Biospecimens

KW - Biotransformation

KW - Comprehensive two-dimensional gas chromatography (GC × GC)

KW - Data reporting

KW - In vitro analyses

KW - Metabolomics

KW - Multitrophic interactions

KW - Sampling

UR - http://www.scopus.com/inward/record.url?scp=85056147901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056147901&partnerID=8YFLogxK

U2 - 10.1016/j.trac.2018.10.015

DO - 10.1016/j.trac.2018.10.015

M3 - Review article

AN - SCOPUS:85056147901

SN - 0165-9936

VL - 109

SP - 275

EP - 286

JO - TrAC - Trends in Analytical Chemistry

JF - TrAC - Trends in Analytical Chemistry

ER -

Advances in the application of comprehensive two-dimensional gas chromatography in metabolomics

Abstract

Keywords

ASJC Scopus subject areas

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