Advances in primary sclerosing cholongitis

Keith Lindor, Russell H. Wiesner, Robert L. MacCarty, Jurgen Ludwig, Nicholas F. Larusso

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Primary sclerosing cholongitis is an increasingly recognized chronic cholestatic liver disease. It frequently occurs in association with chronic ulcerative colitis and is characterized by inflammation and fibrosis of the intrahepatic and extrahepatic bile ducts. The cause is unknown, although many mechanisms have been considered, including infectious, toxic, and immunologic. The prognosis varies. No adequate treatment exists, although a number of potential treatments have been evaluated in uncontrolled trials, and the results of controlled trials have only recently been reported. Liver transplantation has recently been shown to be an effective treatment for end-stage disease. These various advances in our understanding of primary sclerosing cholangitis are reviewed.

Original languageEnglish (US)
Pages (from-to)73-80
Number of pages8
JournalThe American Journal of Medicine
Volume89
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

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Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Sclerosing Cholangitis
Poisons
Ulcerative Colitis
Liver Transplantation
Liver Diseases
Fibrosis
Therapeutics
Inflammation

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Lindor, K., Wiesner, R. H., MacCarty, R. L., Ludwig, J., & Larusso, N. F. (1990). Advances in primary sclerosing cholongitis. The American Journal of Medicine, 89(1), 73-80. https://doi.org/10.1016/0002-9343(90)90101-I

Advances in primary sclerosing cholongitis. / Lindor, Keith; Wiesner, Russell H.; MacCarty, Robert L.; Ludwig, Jurgen; Larusso, Nicholas F.

In: The American Journal of Medicine, Vol. 89, No. 1, 1990, p. 73-80.

Research output: Contribution to journalArticle

Lindor, K, Wiesner, RH, MacCarty, RL, Ludwig, J & Larusso, NF 1990, 'Advances in primary sclerosing cholongitis', The American Journal of Medicine, vol. 89, no. 1, pp. 73-80. https://doi.org/10.1016/0002-9343(90)90101-I
Lindor, Keith ; Wiesner, Russell H. ; MacCarty, Robert L. ; Ludwig, Jurgen ; Larusso, Nicholas F. / Advances in primary sclerosing cholongitis. In: The American Journal of Medicine. 1990 ; Vol. 89, No. 1. pp. 73-80.
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