Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis

Nitish Peela, Danh Truong, Harpinder Saini, Hunghao Chu, Samaneh Mashaghi, Stephanie L. Ham, Sunil Singh, Hossein Tavana, Bobak Mosadegh, Mehdi Nikkhah

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and adapt to a plethora of biochemical and biophysical signals from stromal cells and extracellular matrix (ECM) proteins. Due to these complexities, there is a critical need to understand molecular mechanisms underlying cancer metastasis to facilitate the discovery of more effective therapies. In the past few years, the integration of advanced biomaterials and microengineering approaches has initiated the development of innovative platform technologies for cancer research. These technologies enable the creation of biomimetic in vitro models with physiologically relevant (i.e. in vivo-like) characteristics to conduct studies ranging from fundamental cancer biology to high-throughput drug screening. In this review article, we discuss the biological significance of each step of the metastatic cascade and provide a broad overview on recent progress to recapitulate these stages using advanced biomaterials and microengineered technologies. In each section, we will highlight the advantages and shortcomings of each approach and provide our perspectives on future directions.

Original languageEnglish (US)
Pages (from-to)176-207
Number of pages32
JournalBiomaterials
Volume133
DOIs
StatePublished - Jul 1 2017

Fingerprint

Biocompatible Materials
Biomaterials
Neoplasm Metastasis
Technology
Tumors
Neoplasms
Extracellular Matrix Proteins
Biomimetics
Screening
Cells
Throughput
Health
Proteins
Preclinical Drug Evaluations
Tumor Microenvironment
Pharmaceutical Preparations
Stromal Cells
Early Diagnosis
Cause of Death
Mortality

Keywords

  • Angiogenesis
  • Biomaterials
  • Extravasation
  • Intravasation
  • Microengineering technologies
  • Microfluidics
  • Tumor model

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis. / Peela, Nitish; Truong, Danh; Saini, Harpinder; Chu, Hunghao; Mashaghi, Samaneh; Ham, Stephanie L.; Singh, Sunil; Tavana, Hossein; Mosadegh, Bobak; Nikkhah, Mehdi.

In: Biomaterials, Vol. 133, 01.07.2017, p. 176-207.

Research output: Contribution to journalReview article

Peela, N, Truong, D, Saini, H, Chu, H, Mashaghi, S, Ham, SL, Singh, S, Tavana, H, Mosadegh, B & Nikkhah, M 2017, 'Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis', Biomaterials, vol. 133, pp. 176-207. https://doi.org/10.1016/j.biomaterials.2017.04.017
Peela, Nitish ; Truong, Danh ; Saini, Harpinder ; Chu, Hunghao ; Mashaghi, Samaneh ; Ham, Stephanie L. ; Singh, Sunil ; Tavana, Hossein ; Mosadegh, Bobak ; Nikkhah, Mehdi. / Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis. In: Biomaterials. 2017 ; Vol. 133. pp. 176-207.
@article{3fd845ede1f64f008041961898076efc,
title = "Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis",
abstract = "Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and adapt to a plethora of biochemical and biophysical signals from stromal cells and extracellular matrix (ECM) proteins. Due to these complexities, there is a critical need to understand molecular mechanisms underlying cancer metastasis to facilitate the discovery of more effective therapies. In the past few years, the integration of advanced biomaterials and microengineering approaches has initiated the development of innovative platform technologies for cancer research. These technologies enable the creation of biomimetic in vitro models with physiologically relevant (i.e. in vivo-like) characteristics to conduct studies ranging from fundamental cancer biology to high-throughput drug screening. In this review article, we discuss the biological significance of each step of the metastatic cascade and provide a broad overview on recent progress to recapitulate these stages using advanced biomaterials and microengineered technologies. In each section, we will highlight the advantages and shortcomings of each approach and provide our perspectives on future directions.",
keywords = "Angiogenesis, Biomaterials, Extravasation, Intravasation, Microengineering technologies, Microfluidics, Tumor model",
author = "Nitish Peela and Danh Truong and Harpinder Saini and Hunghao Chu and Samaneh Mashaghi and Ham, {Stephanie L.} and Sunil Singh and Hossein Tavana and Bobak Mosadegh and Mehdi Nikkhah",
year = "2017",
month = "7",
day = "1",
doi = "10.1016/j.biomaterials.2017.04.017",
language = "English (US)",
volume = "133",
pages = "176--207",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis

AU - Peela, Nitish

AU - Truong, Danh

AU - Saini, Harpinder

AU - Chu, Hunghao

AU - Mashaghi, Samaneh

AU - Ham, Stephanie L.

AU - Singh, Sunil

AU - Tavana, Hossein

AU - Mosadegh, Bobak

AU - Nikkhah, Mehdi

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and adapt to a plethora of biochemical and biophysical signals from stromal cells and extracellular matrix (ECM) proteins. Due to these complexities, there is a critical need to understand molecular mechanisms underlying cancer metastasis to facilitate the discovery of more effective therapies. In the past few years, the integration of advanced biomaterials and microengineering approaches has initiated the development of innovative platform technologies for cancer research. These technologies enable the creation of biomimetic in vitro models with physiologically relevant (i.e. in vivo-like) characteristics to conduct studies ranging from fundamental cancer biology to high-throughput drug screening. In this review article, we discuss the biological significance of each step of the metastatic cascade and provide a broad overview on recent progress to recapitulate these stages using advanced biomaterials and microengineered technologies. In each section, we will highlight the advantages and shortcomings of each approach and provide our perspectives on future directions.

AB - Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and adapt to a plethora of biochemical and biophysical signals from stromal cells and extracellular matrix (ECM) proteins. Due to these complexities, there is a critical need to understand molecular mechanisms underlying cancer metastasis to facilitate the discovery of more effective therapies. In the past few years, the integration of advanced biomaterials and microengineering approaches has initiated the development of innovative platform technologies for cancer research. These technologies enable the creation of biomimetic in vitro models with physiologically relevant (i.e. in vivo-like) characteristics to conduct studies ranging from fundamental cancer biology to high-throughput drug screening. In this review article, we discuss the biological significance of each step of the metastatic cascade and provide a broad overview on recent progress to recapitulate these stages using advanced biomaterials and microengineered technologies. In each section, we will highlight the advantages and shortcomings of each approach and provide our perspectives on future directions.

KW - Angiogenesis

KW - Biomaterials

KW - Extravasation

KW - Intravasation

KW - Microengineering technologies

KW - Microfluidics

KW - Tumor model

UR - http://www.scopus.com/inward/record.url?scp=85018482929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018482929&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2017.04.017

DO - 10.1016/j.biomaterials.2017.04.017

M3 - Review article

VL - 133

SP - 176

EP - 207

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

ER -