Adult age differences in frontostriatal representation of prediction error but not reward outcome

Gregory R. Samanez-Larkin, Darrell A. Worthy, Rui Mata, Samuel McClure, Brian Knutson

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Emerging evidence from decision neuroscience suggests that although younger and older adults show similar frontostriatal representations of reward magnitude, older adults often show deficits in feedback-driven reinforcement learning. In the present study, healthy adults completed reward-based tasks that did or did not depend on probabilistic learning, while undergoing functional neuroimaging. We observed reductions in the frontostriatal representation of prediction errors during probabilistic learning in older adults. In contrast, we found evidence for stability across adulthood in the representation of reward outcome in a task that did not require learning. Together, the results identify changes across adulthood in the dynamic coding of relational representations of feedback, in spite of preserved reward sensitivity in old age. Overall, the results suggest that the neural representation of prediction error, but not reward outcome, is reduced in old age. These findings reveal a potential dissociation between cognition and motivation with age and identify a potential mechanism for explaining changes in learning-dependent decision making in old adulthood.

Original languageEnglish (US)
Pages (from-to)672-682
Number of pages11
JournalCognitive, Affective and Behavioral Neuroscience
Volume14
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Reward
Learning
Functional Neuroimaging
Neurosciences
Cognition
Motivation
Young Adult
Decision Making

Keywords

  • Aging
  • Decision making
  • Learning
  • Medial prefrontal cortex
  • Motivation
  • Reward
  • Ventral striatum

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Adult age differences in frontostriatal representation of prediction error but not reward outcome. / Samanez-Larkin, Gregory R.; Worthy, Darrell A.; Mata, Rui; McClure, Samuel; Knutson, Brian.

In: Cognitive, Affective and Behavioral Neuroscience, Vol. 14, No. 2, 2014, p. 672-682.

Research output: Contribution to journalArticle

Samanez-Larkin, Gregory R. ; Worthy, Darrell A. ; Mata, Rui ; McClure, Samuel ; Knutson, Brian. / Adult age differences in frontostriatal representation of prediction error but not reward outcome. In: Cognitive, Affective and Behavioral Neuroscience. 2014 ; Vol. 14, No. 2. pp. 672-682.
@article{21b37d28521c4374914f0ffb68f8d87c,
title = "Adult age differences in frontostriatal representation of prediction error but not reward outcome",
abstract = "Emerging evidence from decision neuroscience suggests that although younger and older adults show similar frontostriatal representations of reward magnitude, older adults often show deficits in feedback-driven reinforcement learning. In the present study, healthy adults completed reward-based tasks that did or did not depend on probabilistic learning, while undergoing functional neuroimaging. We observed reductions in the frontostriatal representation of prediction errors during probabilistic learning in older adults. In contrast, we found evidence for stability across adulthood in the representation of reward outcome in a task that did not require learning. Together, the results identify changes across adulthood in the dynamic coding of relational representations of feedback, in spite of preserved reward sensitivity in old age. Overall, the results suggest that the neural representation of prediction error, but not reward outcome, is reduced in old age. These findings reveal a potential dissociation between cognition and motivation with age and identify a potential mechanism for explaining changes in learning-dependent decision making in old adulthood.",
keywords = "Aging, Decision making, Learning, Medial prefrontal cortex, Motivation, Reward, Ventral striatum",
author = "Samanez-Larkin, {Gregory R.} and Worthy, {Darrell A.} and Rui Mata and Samuel McClure and Brian Knutson",
year = "2014",
doi = "10.3758/s13415-014-0297-4",
language = "English (US)",
volume = "14",
pages = "672--682",
journal = "Cognitive, Affective and Behavioral Neuroscience",
issn = "1530-7026",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Adult age differences in frontostriatal representation of prediction error but not reward outcome

AU - Samanez-Larkin, Gregory R.

AU - Worthy, Darrell A.

AU - Mata, Rui

AU - McClure, Samuel

AU - Knutson, Brian

PY - 2014

Y1 - 2014

N2 - Emerging evidence from decision neuroscience suggests that although younger and older adults show similar frontostriatal representations of reward magnitude, older adults often show deficits in feedback-driven reinforcement learning. In the present study, healthy adults completed reward-based tasks that did or did not depend on probabilistic learning, while undergoing functional neuroimaging. We observed reductions in the frontostriatal representation of prediction errors during probabilistic learning in older adults. In contrast, we found evidence for stability across adulthood in the representation of reward outcome in a task that did not require learning. Together, the results identify changes across adulthood in the dynamic coding of relational representations of feedback, in spite of preserved reward sensitivity in old age. Overall, the results suggest that the neural representation of prediction error, but not reward outcome, is reduced in old age. These findings reveal a potential dissociation between cognition and motivation with age and identify a potential mechanism for explaining changes in learning-dependent decision making in old adulthood.

AB - Emerging evidence from decision neuroscience suggests that although younger and older adults show similar frontostriatal representations of reward magnitude, older adults often show deficits in feedback-driven reinforcement learning. In the present study, healthy adults completed reward-based tasks that did or did not depend on probabilistic learning, while undergoing functional neuroimaging. We observed reductions in the frontostriatal representation of prediction errors during probabilistic learning in older adults. In contrast, we found evidence for stability across adulthood in the representation of reward outcome in a task that did not require learning. Together, the results identify changes across adulthood in the dynamic coding of relational representations of feedback, in spite of preserved reward sensitivity in old age. Overall, the results suggest that the neural representation of prediction error, but not reward outcome, is reduced in old age. These findings reveal a potential dissociation between cognition and motivation with age and identify a potential mechanism for explaining changes in learning-dependent decision making in old adulthood.

KW - Aging

KW - Decision making

KW - Learning

KW - Medial prefrontal cortex

KW - Motivation

KW - Reward

KW - Ventral striatum

UR - http://www.scopus.com/inward/record.url?scp=84904389160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904389160&partnerID=8YFLogxK

U2 - 10.3758/s13415-014-0297-4

DO - 10.3758/s13415-014-0297-4

M3 - Article

C2 - 24853269

AN - SCOPUS:84904389160

VL - 14

SP - 672

EP - 682

JO - Cognitive, Affective and Behavioral Neuroscience

JF - Cognitive, Affective and Behavioral Neuroscience

SN - 1530-7026

IS - 2

ER -