Abstract
The removal of protein-bound substances (endogenous and exogenous toxins) from blood using adsorption media, such as coated activated carbon in hemoperfusion is limited by the inability of the bound toxin to diffuse and adsorb within the absorbent matrix. However, the removal can be significantly augmented by the addition of a biocompatible unbinding agent (solutizer) at the column entrance. A unique combination of a pore diffusion adsorption model and a simplified protein binding model is used to simulate the dynamics of this system. The resulting particle differential equations are solved using the method of lines with finite differences or orthogonal collocation discretization. The theoretical exit concentration profiles are in agreement with preliminary data for the bilirubin (endogenous toxin), benzoate (solutizer), and albumin (protein) mock solution system.
| Original language | English (US) |
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| Title of host publication | American Institute of Chemical Engineers, National Meeting |
| Place of Publication | New York, NY, United States |
| Publisher | Publ by AIChE |
| State | Published - 1988 |
| Event | Preprint - American Institute of Chemical Engineers - New Orleans, LA, USA Duration: Mar 6 1988 → Mar 10 1988 |
Other
| Other | Preprint - American Institute of Chemical Engineers |
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| City | New Orleans, LA, USA |
| Period | 3/6/88 → 3/10/88 |
ASJC Scopus subject areas
- General Engineering