Adsorption model for the removal of protein-bound substances from blood or plasma: Preliminary investigations

Ben F. Brian, William J. Dorson, Vincent Pizziconi, John E. Brooker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The removal of protein-bound substances (endogenous and exogenous toxins) from blood using adsorption media, such as coated activated carbon in hemoperfusion is limited by the inability of the bound toxin to diffuse and adsorb within the absorbent matrix. However, the removal can be significantly augmented by the addition of a biocompatible unbinding agent (solutizer) at the column entrance. A unique combination of a pore diffusion adsorption model and a simplified protein binding model is used to simulate the dynamics of this system. The resulting particle differential equations are solved using the method of lines with finite differences or orthogonal collocation discretization. The theoretical exit concentration profiles are in agreement with preliminary data for the bilirubin (endogenous toxin), benzoate (solutizer), and albumin (protein) mock solution system.

Original languageEnglish (US)
Title of host publicationAmerican Institute of Chemical Engineers, National Meeting
Place of PublicationNew York, NY, United States
PublisherPubl by AIChE
StatePublished - 1988
EventPreprint - American Institute of Chemical Engineers - New Orleans, LA, USA
Duration: Mar 6 1988Mar 10 1988

Other

OtherPreprint - American Institute of Chemical Engineers
CityNew Orleans, LA, USA
Period3/6/883/10/88

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Brian, B. F., Dorson, W. J., Pizziconi, V., & Brooker, J. E. (1988). Adsorption model for the removal of protein-bound substances from blood or plasma: Preliminary investigations. In American Institute of Chemical Engineers, National Meeting Publ by AIChE.