Adrenergic function in patients with panic anxiety

Randolph Nesse, O. G. Cameron, G. C. Curtis, D. S. McCann, M. J. Huber-Smith

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Increased β-adrenergic receptor sensitivity could account for many aspects of panic disorder. We tested the hypothesis by comparing 14 patients with six normal control subjects. The controls and eight patients had 14 blood samples taken, and heart rate and BP measured, during a four-hour protocol that included supine rest, a posture and isometric exercise stimulus, and a series of up to seven logarithmically increasing bolus intravenous doses of isoproterenol hydrochloride. The other six patients were studied only at rest. Patients had markedly elevated resting heart rate, substantially elevated levels of plasma epinephrine, cortisol, and growth hormone, mildly elevated plasma norepinephrine levels, and decreased heart rate responses to isoproterenol. These results suggest that β-adrenergic receptor response is not increased, and may be decreased, in patients with panic disorder. Receptor down-regulation could result from the increased adrenergic function that these patients demonstrate, even in the absence of panic attacks.

Original languageEnglish (US)
Pages (from-to)771-776
Number of pages6
JournalArchives of General Psychiatry
Volume41
Issue number8
StatePublished - 1984
Externally publishedYes

Fingerprint

Panic
Adrenergic Agents
Anxiety
Panic Disorder
Heart Rate
Isoproterenol
Adrenergic Receptors
Posture
Epinephrine
Growth Hormone
Hydrocortisone
Norepinephrine
Down-Regulation
Exercise

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Nesse, R., Cameron, O. G., Curtis, G. C., McCann, D. S., & Huber-Smith, M. J. (1984). Adrenergic function in patients with panic anxiety. Archives of General Psychiatry, 41(8), 771-776.

Adrenergic function in patients with panic anxiety. / Nesse, Randolph; Cameron, O. G.; Curtis, G. C.; McCann, D. S.; Huber-Smith, M. J.

In: Archives of General Psychiatry, Vol. 41, No. 8, 1984, p. 771-776.

Research output: Contribution to journalArticle

Nesse, R, Cameron, OG, Curtis, GC, McCann, DS & Huber-Smith, MJ 1984, 'Adrenergic function in patients with panic anxiety', Archives of General Psychiatry, vol. 41, no. 8, pp. 771-776.
Nesse R, Cameron OG, Curtis GC, McCann DS, Huber-Smith MJ. Adrenergic function in patients with panic anxiety. Archives of General Psychiatry. 1984;41(8):771-776.
Nesse, Randolph ; Cameron, O. G. ; Curtis, G. C. ; McCann, D. S. ; Huber-Smith, M. J. / Adrenergic function in patients with panic anxiety. In: Archives of General Psychiatry. 1984 ; Vol. 41, No. 8. pp. 771-776.
@article{caefa7bf89874795877c631126487687,
title = "Adrenergic function in patients with panic anxiety",
abstract = "Increased β-adrenergic receptor sensitivity could account for many aspects of panic disorder. We tested the hypothesis by comparing 14 patients with six normal control subjects. The controls and eight patients had 14 blood samples taken, and heart rate and BP measured, during a four-hour protocol that included supine rest, a posture and isometric exercise stimulus, and a series of up to seven logarithmically increasing bolus intravenous doses of isoproterenol hydrochloride. The other six patients were studied only at rest. Patients had markedly elevated resting heart rate, substantially elevated levels of plasma epinephrine, cortisol, and growth hormone, mildly elevated plasma norepinephrine levels, and decreased heart rate responses to isoproterenol. These results suggest that β-adrenergic receptor response is not increased, and may be decreased, in patients with panic disorder. Receptor down-regulation could result from the increased adrenergic function that these patients demonstrate, even in the absence of panic attacks.",
author = "Randolph Nesse and Cameron, {O. G.} and Curtis, {G. C.} and McCann, {D. S.} and Huber-Smith, {M. J.}",
year = "1984",
language = "English (US)",
volume = "41",
pages = "771--776",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "8",

}

TY - JOUR

T1 - Adrenergic function in patients with panic anxiety

AU - Nesse, Randolph

AU - Cameron, O. G.

AU - Curtis, G. C.

AU - McCann, D. S.

AU - Huber-Smith, M. J.

PY - 1984

Y1 - 1984

N2 - Increased β-adrenergic receptor sensitivity could account for many aspects of panic disorder. We tested the hypothesis by comparing 14 patients with six normal control subjects. The controls and eight patients had 14 blood samples taken, and heart rate and BP measured, during a four-hour protocol that included supine rest, a posture and isometric exercise stimulus, and a series of up to seven logarithmically increasing bolus intravenous doses of isoproterenol hydrochloride. The other six patients were studied only at rest. Patients had markedly elevated resting heart rate, substantially elevated levels of plasma epinephrine, cortisol, and growth hormone, mildly elevated plasma norepinephrine levels, and decreased heart rate responses to isoproterenol. These results suggest that β-adrenergic receptor response is not increased, and may be decreased, in patients with panic disorder. Receptor down-regulation could result from the increased adrenergic function that these patients demonstrate, even in the absence of panic attacks.

AB - Increased β-adrenergic receptor sensitivity could account for many aspects of panic disorder. We tested the hypothesis by comparing 14 patients with six normal control subjects. The controls and eight patients had 14 blood samples taken, and heart rate and BP measured, during a four-hour protocol that included supine rest, a posture and isometric exercise stimulus, and a series of up to seven logarithmically increasing bolus intravenous doses of isoproterenol hydrochloride. The other six patients were studied only at rest. Patients had markedly elevated resting heart rate, substantially elevated levels of plasma epinephrine, cortisol, and growth hormone, mildly elevated plasma norepinephrine levels, and decreased heart rate responses to isoproterenol. These results suggest that β-adrenergic receptor response is not increased, and may be decreased, in patients with panic disorder. Receptor down-regulation could result from the increased adrenergic function that these patients demonstrate, even in the absence of panic attacks.

UR - http://www.scopus.com/inward/record.url?scp=0021256271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021256271&partnerID=8YFLogxK

M3 - Article

C2 - 6331337

AN - SCOPUS:0021256271

VL - 41

SP - 771

EP - 776

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 8

ER -