Adiposity, plasma insulin, leptin, lipids, and oxidative stress in mature light breed horses

R. S. Pleasant, J. K. Suagee, Craig Thatcher, F. Elvinger, R. J. Geor

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Increased blood insulin levels are associated with an increased risk of pasture-associated laminitis in equids. Objective: To determine the relationship between plasma insulin, leptin, and lipid levels, and measures of oxidative stress with adiposity in mature light breed horses. Animals: 300 randomly selected light breed horses, aged 4-20 years. Methods: A random sample of horses (140 mares, 151 geldings, and 9 stallions) was drawn from the VMRCVM Equine Field Service practice client list. Evaluations occurred June 15 - August 15, 2006, with all sampling performed between 0600 and 1200 hours. Concentrate feed was withheld for at least 10 hours before sampling. Plasma was analyzed for insulin, glucose, leptin, triglycerides, nonesterified fatty acids, and measures of oxidative stress. Body condition score was determined as the average of 2 independent investigators. Results: Overconditioned and obese horses had higher plasma insulin (P < .001) and leptin (P < .01) levels than optimally conditioned horses. Obese horses had higher triglyceride levels (P = .006) and lower red blood cell gluthathione peroxidase activities (P = .001) than optimally conditioned horses. Conclusions and Clinical Importance: Maintaining horses at a BCS <7 might be important for decreasing the risk of pasture-associated laminitis.

Original languageEnglish (US)
Pages (from-to)576-582
Number of pages7
JournalJournal of Veterinary Internal Medicine
Volume27
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

horse breeds
Adiposity
adiposity
Leptin
leptin
Horses
Oxidative Stress
oxidative stress
insulin
Insulin
Lipids
horses
Light
lipids
laminitis
triacylglycerols
pastures
Triglycerides
geldings
feed concentrates

Keywords

  • Body condition
  • Equine metabolic syndrome
  • Leptin
  • Lipids
  • Plasma insulin

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Adiposity, plasma insulin, leptin, lipids, and oxidative stress in mature light breed horses. / Pleasant, R. S.; Suagee, J. K.; Thatcher, Craig; Elvinger, F.; Geor, R. J.

In: Journal of Veterinary Internal Medicine, Vol. 27, No. 3, 05.2013, p. 576-582.

Research output: Contribution to journalArticle

Pleasant, R. S. ; Suagee, J. K. ; Thatcher, Craig ; Elvinger, F. ; Geor, R. J. / Adiposity, plasma insulin, leptin, lipids, and oxidative stress in mature light breed horses. In: Journal of Veterinary Internal Medicine. 2013 ; Vol. 27, No. 3. pp. 576-582.
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