Abstract
Background: Increased blood insulin levels are associated with an increased risk of pasture-associated laminitis in equids. Objective: To determine the relationship between plasma insulin, leptin, and lipid levels, and measures of oxidative stress with adiposity in mature light breed horses. Animals: 300 randomly selected light breed horses, aged 4-20 years. Methods: A random sample of horses (140 mares, 151 geldings, and 9 stallions) was drawn from the VMRCVM Equine Field Service practice client list. Evaluations occurred June 15 - August 15, 2006, with all sampling performed between 0600 and 1200 hours. Concentrate feed was withheld for at least 10 hours before sampling. Plasma was analyzed for insulin, glucose, leptin, triglycerides, nonesterified fatty acids, and measures of oxidative stress. Body condition score was determined as the average of 2 independent investigators. Results: Overconditioned and obese horses had higher plasma insulin (P < .001) and leptin (P < .01) levels than optimally conditioned horses. Obese horses had higher triglyceride levels (P = .006) and lower red blood cell gluthathione peroxidase activities (P = .001) than optimally conditioned horses. Conclusions and Clinical Importance: Maintaining horses at a BCS <7 might be important for decreasing the risk of pasture-associated laminitis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 576-582 |
| Number of pages | 7 |
| Journal | Journal of Veterinary Internal Medicine |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 2013 |
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Keywords
- Body condition
- Equine metabolic syndrome
- Leptin
- Lipids
- Plasma insulin
ASJC Scopus subject areas
- veterinary(all)
Cite this
Adiposity, plasma insulin, leptin, lipids, and oxidative stress in mature light breed horses. / Pleasant, R. S.; Suagee, J. K.; Thatcher, Craig; Elvinger, F.; Geor, R. J.
In: Journal of Veterinary Internal Medicine, Vol. 27, No. 3, 05.2013, p. 576-582.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adiposity, plasma insulin, leptin, lipids, and oxidative stress in mature light breed horses
AU - Pleasant, R. S.
AU - Suagee, J. K.
AU - Thatcher, Craig
AU - Elvinger, F.
AU - Geor, R. J.
PY - 2013/5
Y1 - 2013/5
N2 - Background: Increased blood insulin levels are associated with an increased risk of pasture-associated laminitis in equids. Objective: To determine the relationship between plasma insulin, leptin, and lipid levels, and measures of oxidative stress with adiposity in mature light breed horses. Animals: 300 randomly selected light breed horses, aged 4-20 years. Methods: A random sample of horses (140 mares, 151 geldings, and 9 stallions) was drawn from the VMRCVM Equine Field Service practice client list. Evaluations occurred June 15 - August 15, 2006, with all sampling performed between 0600 and 1200 hours. Concentrate feed was withheld for at least 10 hours before sampling. Plasma was analyzed for insulin, glucose, leptin, triglycerides, nonesterified fatty acids, and measures of oxidative stress. Body condition score was determined as the average of 2 independent investigators. Results: Overconditioned and obese horses had higher plasma insulin (P < .001) and leptin (P < .01) levels than optimally conditioned horses. Obese horses had higher triglyceride levels (P = .006) and lower red blood cell gluthathione peroxidase activities (P = .001) than optimally conditioned horses. Conclusions and Clinical Importance: Maintaining horses at a BCS <7 might be important for decreasing the risk of pasture-associated laminitis.
AB - Background: Increased blood insulin levels are associated with an increased risk of pasture-associated laminitis in equids. Objective: To determine the relationship between plasma insulin, leptin, and lipid levels, and measures of oxidative stress with adiposity in mature light breed horses. Animals: 300 randomly selected light breed horses, aged 4-20 years. Methods: A random sample of horses (140 mares, 151 geldings, and 9 stallions) was drawn from the VMRCVM Equine Field Service practice client list. Evaluations occurred June 15 - August 15, 2006, with all sampling performed between 0600 and 1200 hours. Concentrate feed was withheld for at least 10 hours before sampling. Plasma was analyzed for insulin, glucose, leptin, triglycerides, nonesterified fatty acids, and measures of oxidative stress. Body condition score was determined as the average of 2 independent investigators. Results: Overconditioned and obese horses had higher plasma insulin (P < .001) and leptin (P < .01) levels than optimally conditioned horses. Obese horses had higher triglyceride levels (P = .006) and lower red blood cell gluthathione peroxidase activities (P = .001) than optimally conditioned horses. Conclusions and Clinical Importance: Maintaining horses at a BCS <7 might be important for decreasing the risk of pasture-associated laminitis.
KW - Body condition
KW - Equine metabolic syndrome
KW - Leptin
KW - Lipids
KW - Plasma insulin
UR - http://www.scopus.com/inward/record.url?scp=84877672761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84877672761&partnerID=8YFLogxK
U2 - 10.1111/jvim.12056
DO - 10.1111/jvim.12056
M3 - Article
C2 - 23517373
AN - SCOPUS:84877672761
VL - 27
SP - 576
EP - 582
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 3
ER -