@article{f0def3df40a24b7a98592aadf6d347f9,
title = "Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis",
abstract = "Vascular endothelial growth factor A (VEGF) is highly expressed in adipose tissue. Its role, however, has not been fully elucidated. Here, we reveal the metabolic role of adipose-VEGF by studying mice with deletion (VEGF AdΔ) or doxycycline-inducible overexpression of a VEGF transgene (VEGFAdTg) in the adipose tissue. VEGFAdΔ mice have reduced adipose vascular density and show adipose hypoxia, apoptosis, inflammation, and metabolic defects on a high-fat diet. In contrast, induction of VEGF expression in VEGFAdTg mice leads to increased adipose vasculature and reduced hypoxia. The latter changes are sufficient to counteract an established compromising effect of high-fat diet on the metabolism, indicating that metabolic misbalance is reversible by adipose vessel density increase. Our data clearly show the essential role of VEGF signaling for adequate adipose function. Besides revealing insights into the molecular mechanisms of obesity-related metabolic diseases, this study points to the therapeutic potential of increased adipose angiogenesis.",
author = "Sung, {Hoon Ki} and Doh, {Kyung Oh} and Son, {Joe Eun} and Park, {Jin Gyoon} and Yunui Bae and Soojeong Choi and Nelson, {Seana Mary Lunney} and Rebecca Cowling and Kristina Nagy and Michael, {Iacovos P.} and Koh, {Gou Young} and Adamson, {S. Lee} and Tony Pawson and Andras Nagy",
note = "Funding Information: We would like to thank Drs. Patrick Tam and Daniel J. Drucker for critical reading of the manuscript. We also thank Dawei Qu, Ken Harpal, John Hsien, and Ariana Karanxha for their excellent technical support. We are grateful to Drs. So-Young Park, Yong Woon Kim, and Jae Ryong Kim at Yeungnam University, Korea, for the critical discussion and intellectual input. We would like to thank the staff of the Toronto Centre for Phenogenomics (TCP), especially Michael Copada, for excellent technical support. H.-K.S. was a recipient of the Gail Posluns Fellowship in Haematology (2007–2009). J.G.P. was a recipient of a Canadian Institutes of Health Research Fellowship (2006–2009). This work was supported by a grant to A.N. from NCIC-Terry Fox Foundation (105268), supported in part by a National Research Foundation of Korea (NRF) grant to Medical Research Center at Yeungnam University (K.-O.D.), and funded by the Korea government (MEST) (2011-0006185) and by a Premier{\textquoteright}s Summit Award to T.P. ",
year = "2013",
month = jan,
day = "8",
doi = "10.1016/j.cmet.2012.12.010",
language = "English (US)",
volume = "17",
pages = "61--72",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "1",
}