Adherence enhancers in pill-related clinical trials: A health behavior in cancer prevention model-based approach

J. R. Atwood, L. Giordano, P. Vargas, G. G. Blackwell, D. L. Earnest, F. Meyskens, D. Alberts

Research output: Contribution to journalArticle

1 Scopus citations


Preventing non-adherence and treating adherence failure are important to consider in designing community-based clinical trials. The approach and methods for managing adherence are vital. This paper describes a practical and theoretically-based strategy for managing adherence in a small cancer prevention trial with subjects (n = 40) taking a non-steroidal anti- inflammatory drug, piroxicam. Average daily pill intake adherence was exceptionally high (97.4%) as measured by self-report calendar. Thus, the generalized adherence enhancement approach used in this study may have been a related factor, although statistical model-testing was not possible in this small trial. The generalized intervention took into account factors such as the potential barriers and benefits of being in the study, self-efficacy and satisfaction with the participant/staff relationship. These and other theoretical variables were incorporated into an overall adherence strategy that is discussed.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalPatient Education and Counseling
Issue number1
StatePublished - Jun 1996



  • Adherence
  • Cancer prevention
  • Compliance

ASJC Scopus subject areas

  • Medicine(all)

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