Adherence enhancers in pill-related clinical trials: A health behavior in cancer prevention model-based approach

J. R. Atwood; L. Giordano; P. Vargas; G. G. Blackwell; D. L. Earnest; F. Meyskens; D. Alberts

doi:10.1016/0738-3991(96)00858-0

Adherence enhancers in pill-related clinical trials: A health behavior in cancer prevention model-based approach

J. R. Atwood, L. Giordano, P. Vargas, G. G. Blackwell, D. L. Earnest, F. Meyskens, D. Alberts

Social and Behavioral Sciences, School of (SSBS)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Preventing non-adherence and treating adherence failure are important to consider in designing community-based clinical trials. The approach and methods for managing adherence are vital. This paper describes a practical and theoretically-based strategy for managing adherence in a small cancer prevention trial with subjects (n = 40) taking a non-steroidal anti- inflammatory drug, piroxicam. Average daily pill intake adherence was exceptionally high (97.4%) as measured by self-report calendar. Thus, the generalized adherence enhancement approach used in this study may have been a related factor, although statistical model-testing was not possible in this small trial. The generalized intervention took into account factors such as the potential barriers and benefits of being in the study, self-efficacy and satisfaction with the participant/staff relationship. These and other theoretical variables were incorporated into an overall adherence strategy that is discussed.

Original language	English (US)
Pages (from-to)	15-23
Number of pages	9
Journal	Patient Education and Counseling
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0738-3991(96)00858-0
State	Published - Jun 1996

Keywords

Adherence
Cancer prevention
Compliance

ASJC Scopus subject areas

General Medicine

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title = "Adherence enhancers in pill-related clinical trials: A health behavior in cancer prevention model-based approach",

abstract = "Preventing non-adherence and treating adherence failure are important to consider in designing community-based clinical trials. The approach and methods for managing adherence are vital. This paper describes a practical and theoretically-based strategy for managing adherence in a small cancer prevention trial with subjects (n = 40) taking a non-steroidal anti- inflammatory drug, piroxicam. Average daily pill intake adherence was exceptionally high (97.4%) as measured by self-report calendar. Thus, the generalized adherence enhancement approach used in this study may have been a related factor, although statistical model-testing was not possible in this small trial. The generalized intervention took into account factors such as the potential barriers and benefits of being in the study, self-efficacy and satisfaction with the participant/staff relationship. These and other theoretical variables were incorporated into an overall adherence strategy that is discussed.",

keywords = "Adherence, Cancer prevention, Compliance",

author = "Atwood, {J. R.} and L. Giordano and P. Vargas and Blackwell, {G. G.} and Earnest, {D. L.} and F. Meyskens and D. Alberts",

note = "Funding Information: Funding sources: Colon Cancer Prevention Program Project, David Alberts, P.I. NC1 CA41108 and Arizona Cancer Center Core Grant, Sydney Salmon, P.I. NC1 CA23074.",

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AU - Blackwell, G. G.

AU - Earnest, D. L.

AU - Meyskens, F.

AU - Alberts, D.

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AB - Preventing non-adherence and treating adherence failure are important to consider in designing community-based clinical trials. The approach and methods for managing adherence are vital. This paper describes a practical and theoretically-based strategy for managing adherence in a small cancer prevention trial with subjects (n = 40) taking a non-steroidal anti- inflammatory drug, piroxicam. Average daily pill intake adherence was exceptionally high (97.4%) as measured by self-report calendar. Thus, the generalized adherence enhancement approach used in this study may have been a related factor, although statistical model-testing was not possible in this small trial. The generalized intervention took into account factors such as the potential barriers and benefits of being in the study, self-efficacy and satisfaction with the participant/staff relationship. These and other theoretical variables were incorporated into an overall adherence strategy that is discussed.

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Adherence enhancers in pill-related clinical trials: A health behavior in cancer prevention model-based approach

Abstract

Keywords

ASJC Scopus subject areas

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