Acute reserpine administration elicits long-term spontaneous oral dyskinesia

Amy N. Sussman, Ly T L Tran-Nguyen, Janet Neisewander

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Chronic reserpine administration produces persistent oral dyskinesia accompanied by severe dopamine depletion in the caudate-putamen. The present study examined whether these behavioral and neurochemical effects would persist following acute reserpine administration. Acute administration of reserpine (1 mg/kg, s.c.) produced spontaneous oral dyskinesia that persisted above control levels for at least 84 days. Reserpine also produced a 74% depletion of dopamine in the caudate-putamen relative to vehicle treatment at 3 days post-injection, but did not significantly alter dopamine in the caudate-putamen at 84 days post-injection. The finding that reserpine-induced oral dyskinesia persisted despite repletion of dopamine in the caudate-putamen suggests that the persistent neuropathological change underlying this behavior occurs in a neural pathway other than the dopaminergic nigrostriatal pathway.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalEuropean Journal of Pharmacology
Volume337
Issue number2-3
DOIs
StatePublished - Oct 22 1997

Keywords

  • Dopamine
  • Oral dyskinesia
  • Reserpine
  • Tardive dyskinesia
  • Tongue protrusion

ASJC Scopus subject areas

  • Pharmacology

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