Acute human brain responses to intracortical microelectrode arrays: Challenges and future prospects

Eduardo Fernández, Bradley Greger, Paul A. House, Ignacio Aranda, Carlos Botella, Julio Albisua, Cristina Soto-Sánchez, Arantxa Alfaro, Richard A. Normann

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The emerging field of neuroprosthetics is focused on the development of new therapeutic interventions that will be able to restore some lost neural function by selective electrical stimulation or by harnessing activity recorded from populations of neurons. As more and more patients benefit from these approaches, the interest in neural interfaces has grown significantly and a new generation of penetrating microelectrode arrays are providing unprecedented access to the neurons of the central nervous system (CNS). These microelectrodes have active tip dimensions that are similar in size to neurons and because they penetrate the nervous system, they provide selective access to these cells (within a few microns). However, the very long-term viability of chronically implanted microelectrodes and the capability of recording the same spiking activity over long time periods still remain to be established and confirmed in human studies. Here we review the main responses to acute implantation of microelectrode arrays, and emphasize that it will become essential to control the neural tissue damage induced by these intracortical microelectrodes in order to achieve the high clinical potentials accompanying this technology.

Original languageEnglish (US)
Article number24
JournalFrontiers in Neuroengineering
Volume7
Issue numberJUL
DOIs
StatePublished - Jul 21 2014

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Microelectrodes
Brain
Neurons
Neurology
Nervous System
Electric Stimulation
Central Nervous System
Tissue
Technology
Population

Keywords

  • Biocompatibility
  • In vivo recording
  • Intracortical microelectrode
  • Neural prosthesis
  • Neurosurgery

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biophysics
  • Neuroscience (miscellaneous)

Cite this

Acute human brain responses to intracortical microelectrode arrays : Challenges and future prospects. / Fernández, Eduardo; Greger, Bradley; House, Paul A.; Aranda, Ignacio; Botella, Carlos; Albisua, Julio; Soto-Sánchez, Cristina; Alfaro, Arantxa; Normann, Richard A.

In: Frontiers in Neuroengineering, Vol. 7, No. JUL, 24, 21.07.2014.

Research output: Contribution to journalArticle

Fernández, E, Greger, B, House, PA, Aranda, I, Botella, C, Albisua, J, Soto-Sánchez, C, Alfaro, A & Normann, RA 2014, 'Acute human brain responses to intracortical microelectrode arrays: Challenges and future prospects', Frontiers in Neuroengineering, vol. 7, no. JUL, 24. https://doi.org/10.3389/fneng.2014.00024
Fernández, Eduardo ; Greger, Bradley ; House, Paul A. ; Aranda, Ignacio ; Botella, Carlos ; Albisua, Julio ; Soto-Sánchez, Cristina ; Alfaro, Arantxa ; Normann, Richard A. / Acute human brain responses to intracortical microelectrode arrays : Challenges and future prospects. In: Frontiers in Neuroengineering. 2014 ; Vol. 7, No. JUL.
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