Activation of oxygen by Fe· bleomycin

A. Natrajan; J. R. Barr; R. B. Van Atta; R. L. Mullholland; Sidney Hecht

Activation of oxygen by Fe· bleomycin

A. Natrajan, J. R. Barr, R. B. Van Atta, R. L. Mullholland, Sidney Hecht

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Bleomycin (BLM) is an antitumor antibiotic that is believed to mediate its therapeutic effects at the level of DNA scission. Strand scission by bleomycin requires the presence of a redox active metal such as Fe, Cu or Mn, and a source of oxygen; there is increasing evidence that BLM-mediated DNA degradation is mediated by a ternary complex of BLM, the redox active metal ion and oxygen, and that information of the ternary complex involves reductive activation of oxygen. Presently, the authors demonstrate that activation of dioxygen by Fe(II)·BLM results in the formation of two equivalents of H ₂O where no substrate is present, and that the conversion requires the expected 4 electrons. Further, it is shows that the activated Fe·BLM is formed by heterolytic cleavage of the O-O bond.

Original language	English (US)
Title of host publication	American Chemical Society, Division of Petroleum Chemistry, Preprints
Publisher	Publ by ACS
Pages	164-167
Number of pages	4
Volume	35
Edition	2
State	Published - Apr 1990
Externally published	Yes
Event	Symposium on Selective Catalytic Oxidation of Hydrocarbons - Presented before the Division of Petroleum Chemistry, ACS, Boston Meeting - Boston, MA, USA Duration: Apr 22 1990 → Apr 27 1990

Other

Other	Symposium on Selective Catalytic Oxidation of Hydrocarbons - Presented before the Division of Petroleum Chemistry, ACS, Boston Meeting
City	Boston, MA, USA
Period	4/22/90 → 4/27/90

ASJC Scopus subject areas

Fuel Technology
General Engineering

Cite this

Natrajan, A, Barr, JR, Van Atta, RB, Mullholland, RL & Hecht, S 1990, Activation of oxygen by Fe· bleomycin. in American Chemical Society, Division of Petroleum Chemistry, Preprints. 2 edn, vol. 35, Publ by ACS, pp. 164-167, Symposium on Selective Catalytic Oxidation of Hydrocarbons - Presented before the Division of Petroleum Chemistry, ACS, Boston Meeting, Boston, MA, USA, 4/22/90.

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title = "Activation of oxygen by Fe· bleomycin",

abstract = "Bleomycin (BLM) is an antitumor antibiotic that is believed to mediate its therapeutic effects at the level of DNA scission. Strand scission by bleomycin requires the presence of a redox active metal such as Fe, Cu or Mn, and a source of oxygen; there is increasing evidence that BLM-mediated DNA degradation is mediated by a ternary complex of BLM, the redox active metal ion and oxygen, and that information of the ternary complex involves reductive activation of oxygen. Presently, the authors demonstrate that activation of dioxygen by Fe(II)·BLM results in the formation of two equivalents of H 2O where no substrate is present, and that the conversion requires the expected 4 electrons. Further, it is shows that the activated Fe·BLM is formed by heterolytic cleavage of the O-O bond. ",

author = "A. Natrajan and Barr, {J. R.} and {Van Atta}, {R. B.} and Mullholland, {R. L.} and Sidney Hecht",

year = "1990",

month = apr,

language = "English (US)",

volume = "35",

pages = "164--167",

booktitle = "American Chemical Society, Division of Petroleum Chemistry, Preprints",

publisher = "Publ by ACS",

edition = "2",

note = "Symposium on Selective Catalytic Oxidation of Hydrocarbons - Presented before the Division of Petroleum Chemistry, ACS, Boston Meeting ; Conference date: 22-04-1990 Through 27-04-1990",

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TY - GEN

T1 - Activation of oxygen by Fe· bleomycin

AU - Natrajan, A.

AU - Barr, J. R.

AU - Van Atta, R. B.

AU - Mullholland, R. L.

AU - Hecht, Sidney

PY - 1990/4

Y1 - 1990/4

N2 - Bleomycin (BLM) is an antitumor antibiotic that is believed to mediate its therapeutic effects at the level of DNA scission. Strand scission by bleomycin requires the presence of a redox active metal such as Fe, Cu or Mn, and a source of oxygen; there is increasing evidence that BLM-mediated DNA degradation is mediated by a ternary complex of BLM, the redox active metal ion and oxygen, and that information of the ternary complex involves reductive activation of oxygen. Presently, the authors demonstrate that activation of dioxygen by Fe(II)·BLM results in the formation of two equivalents of H 2O where no substrate is present, and that the conversion requires the expected 4 electrons. Further, it is shows that the activated Fe·BLM is formed by heterolytic cleavage of the O-O bond.

AB - Bleomycin (BLM) is an antitumor antibiotic that is believed to mediate its therapeutic effects at the level of DNA scission. Strand scission by bleomycin requires the presence of a redox active metal such as Fe, Cu or Mn, and a source of oxygen; there is increasing evidence that BLM-mediated DNA degradation is mediated by a ternary complex of BLM, the redox active metal ion and oxygen, and that information of the ternary complex involves reductive activation of oxygen. Presently, the authors demonstrate that activation of dioxygen by Fe(II)·BLM results in the formation of two equivalents of H 2O where no substrate is present, and that the conversion requires the expected 4 electrons. Further, it is shows that the activated Fe·BLM is formed by heterolytic cleavage of the O-O bond.

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M3 - Conference contribution

AN - SCOPUS:0025410606

VL - 35

SP - 164

EP - 167

BT - American Chemical Society, Division of Petroleum Chemistry, Preprints

PB - Publ by ACS

T2 - Symposium on Selective Catalytic Oxidation of Hydrocarbons - Presented before the Division of Petroleum Chemistry, ACS, Boston Meeting

Y2 - 22 April 1990 through 27 April 1990

ER -

Activation of oxygen by Fe· bleomycin

Abstract

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ASJC Scopus subject areas

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