Activation of oxygen by Fe· bleomycin

A. Natrajan, J. R. Barr, R. B. Van Atta, R. L. Mullholland, Sidney Hecht

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Bleomycin (BLM) is an antitumor antibiotic that is believed to mediate its therapeutic effects at the level of DNA scission. Strand scission by bleomycin requires the presence of a redox active metal such as Fe, Cu or Mn, and a source of oxygen; there is increasing evidence that BLM-mediated DNA degradation is mediated by a ternary complex of BLM, the redox active metal ion and oxygen, and that information of the ternary complex involves reductive activation of oxygen. Presently, the authors demonstrate that activation of dioxygen by Fe(II)·BLM results in the formation of two equivalents of H 2O where no substrate is present, and that the conversion requires the expected 4 electrons. Further, it is shows that the activated Fe·BLM is formed by heterolytic cleavage of the O-O bond.

Original languageEnglish (US)
Title of host publicationAmerican Chemical Society, Division of Petroleum Chemistry, Preprints
PublisherPubl by ACS
Pages164-167
Number of pages4
Volume35
Edition2
StatePublished - Apr 1990
Externally publishedYes
EventSymposium on Selective Catalytic Oxidation of Hydrocarbons - Presented before the Division of Petroleum Chemistry, ACS, Boston Meeting - Boston, MA, USA
Duration: Apr 22 1990Apr 27 1990

Other

OtherSymposium on Selective Catalytic Oxidation of Hydrocarbons - Presented before the Division of Petroleum Chemistry, ACS, Boston Meeting
CityBoston, MA, USA
Period4/22/904/27/90

ASJC Scopus subject areas

  • Fuel Technology
  • Engineering(all)

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  • Cite this

    Natrajan, A., Barr, J. R., Van Atta, R. B., Mullholland, R. L., & Hecht, S. (1990). Activation of oxygen by Fe· bleomycin. In American Chemical Society, Division of Petroleum Chemistry, Preprints (2 ed., Vol. 35, pp. 164-167). Publ by ACS.