Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

Rajnish A. Gupta, Dingzhi Wang, Sharada Katkuri, Haibin Wang, Sudhansu K. Dey, Raymond N. DuBois

Research output: Contribution to journalArticlepeer-review

242 Scopus citations

Abstract

We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.

Original languageEnglish (US)
Pages (from-to)245-247
Number of pages3
JournalNature Medicine
Volume10
Issue number3
DOIs
StatePublished - Mar 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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