Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

Rajnish A. Gupta; Dingzhi Wang; Sharada Katkuri; Haibin Wang; Sudhansu K. Dey; Raymond N. DuBois

doi:10.1038/nm993

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

Rajnish A. Gupta, Dingzhi Wang, Sharada Katkuri, Haibin Wang, Sudhansu K. Dey, Raymond N. DuBois

Research output: Contribution to journal › Article › peer-review

258 Scopus citations

Abstract

We treated Apc^min mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.

Original language	English (US)
Pages (from-to)	245-247
Number of pages	3
Journal	Nature Medicine
Volume	10
Issue number	3
DOIs	https://doi.org/10.1038/nm993
State	Published - Mar 2004
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth",

abstract = "We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.",

author = "Gupta, {Rajnish A.} and Dingzhi Wang and Sharada Katkuri and Haibin Wang and Dey, {Sudhansu K.} and DuBois, {Raymond N.}",

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AU - Gupta, Rajnish A.

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AU - Wang, Haibin

AU - Dey, Sudhansu K.

AU - DuBois, Raymond N.

PY - 2004/3

Y1 - 2004/3

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AB - We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.

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Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

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