Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications

Peiming Zhang, Natalia Briones, Chang Gong Liu, Charles K. Brush, Tom Powdrill, Yuri Belosludtsev, Mike Hogan

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A series of peptides containing histidine residues were designed as potential hybridization rate enhancers within a polymeric matrix of DNA microarrays. The polymeric matrix modified with these peptides showed strong attraction to DNA molecules under conditions of induction. DNA probes on the peptide modified sites rapidly hybridized to their complementary targets with single base pair mismatch discrimination.

Original languageEnglish (US)
Pages (from-to)1251-1254
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number4-7
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Genetics

Fingerprint Dive into the research topics of 'Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications'. Together they form a unique fingerprint.

Cite this