Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications

Peiming Zhang, N. Briones, C. G. Liu, C. K. Brush, T. Powdrill, Y. Belosludtsev, M. Hogan

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A series of peptides containing histidine residues were designed as potential hybridization rate enhancers within a polymeric matrix of DNA microarrays. The polymeric matrix modified with these peptides showed strong attraction to DNA molecules under conditions of induction. DNA probes on the peptide modified sites rapidly hybridized to their complementary targets with single base pair mismatch discrimination.

Original languageEnglish (US)
Pages (from-to)1251-1254
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number4-7
DOIs
Publication statusPublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Biochemistry

Cite this

Zhang, P., Briones, N., Liu, C. G., Brush, C. K., Powdrill, T., Belosludtsev, Y., & Hogan, M. (2001). Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications. Nucleosides, Nucleotides and Nucleic Acids, 20(4-7), 1251-1254. https://doi.org/10.1081/NCN-100002529