Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications

Peiming Zhang; Natalia Briones; Chang Gong Liu; Charles K. Brush; Tom Powdrill; Yuri Belosludtsev; Mike Hogan

doi:10.1081/NCN-100002529

Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications

Peiming Zhang, Natalia Briones, Chang Gong Liu, Charles K. Brush, Tom Powdrill, Yuri Belosludtsev, Mike Hogan

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A series of peptides containing histidine residues were designed as potential hybridization rate enhancers within a polymeric matrix of DNA microarrays. The polymeric matrix modified with these peptides showed strong attraction to DNA molecules under conditions of induction. DNA probes on the peptide modified sites rapidly hybridized to their complementary targets with single base pair mismatch discrimination.

Original language	English (US)
Pages (from-to)	1251-1254
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	20
Issue number	4-7
DOIs	https://doi.org/10.1081/NCN-100002529
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Genetics

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10.1081/NCN-100002529

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title = "Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications",

abstract = "A series of peptides containing histidine residues were designed as potential hybridization rate enhancers within a polymeric matrix of DNA microarrays. The polymeric matrix modified with these peptides showed strong attraction to DNA molecules under conditions of induction. DNA probes on the peptide modified sites rapidly hybridized to their complementary targets with single base pair mismatch discrimination.",

author = "Peiming Zhang and Natalia Briones and Liu, {Chang Gong} and Brush, {Charles K.} and Tom Powdrill and Yuri Belosludtsev and Mike Hogan",

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AU - Zhang, Peiming

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AU - Powdrill, Tom

AU - Belosludtsev, Yuri

AU - Hogan, Mike

PY - 2001

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AB - A series of peptides containing histidine residues were designed as potential hybridization rate enhancers within a polymeric matrix of DNA microarrays. The polymeric matrix modified with these peptides showed strong attraction to DNA molecules under conditions of induction. DNA probes on the peptide modified sites rapidly hybridized to their complementary targets with single base pair mismatch discrimination.

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Acceleration of nucleic acid hybridization on DNA microarrays driven by pH tunable modifications

Abstract

ASJC Scopus subject areas

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