Accelerating locomotor recovery after incomplete spinal injury

Brian K. Hillen, James Abbas, Ranu Jung

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A traumatic spinal injury can destroy cells, irreparably damage axons, and trigger a cascade of biochemical responses that increase the extent of injury. Although damaged central nervous system axons do not regrow well naturally, the distributed nature of the nervous system and its capacity to adapt provide opportunities for recovery of function. It is apparent that activity-dependent plasticity plays a role in this recovery and that the endogenous response to injury heightens the capacity for recovery for at least several weeks postinjury. To restore locomotor function, researchers have investigated the use of treadmill-based training, robots, and electrical stimulation to tap into adaptive activity-dependent processes. The current challenge is to maximize the degree of functional recovery. This manuscript reviews the endogenous neural system response to injury, and reviews data and presents novel analyses of these from a rat model of contusion injury that demonstrates how a targeted intervention can accelerate recovery, presumably by engaging processes that underlie activity-dependent plasticity.

Original languageEnglish (US)
Pages (from-to)164-174
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume1279
Issue number1
DOIs
StatePublished - Apr 2013

Fingerprint

Spinal Injuries
Recovery
Wounds and Injuries
Axons
Neurology
Plasticity
Contusions
Recovery of Function
Exercise equipment
Nervous System
Electric Stimulation
Central Nervous System
Research Personnel
Rats
Incomplete
Robots

Keywords

  • Coordination
  • Electrical stimulation
  • Kinematics
  • Locomotion
  • Plasticity
  • Spinal cord injury

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Accelerating locomotor recovery after incomplete spinal injury. / Hillen, Brian K.; Abbas, James; Jung, Ranu.

In: Annals of the New York Academy of Sciences, Vol. 1279, No. 1, 04.2013, p. 164-174.

Research output: Contribution to journalArticle

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