Accelerated aging in adults with knee osteoarthritis pain: Consideration for frequency, intensity, time, and total pain sites

Kimberly T. Sibille, Huaihou Chen, Emily J. Bartley, Joseph Riley, Toni L. Glover, Christopher D. King, Hang Zhang, Yenisel Cruz-Almeida, Burel R. Goodin, Adriana Sotolongo, Megan Petrov, Matthew Herbert, Hailey W. Bulls, Jeffrey C. Edberg, Roland Staud, David Redden, Laurence A. Bradley, Roger B. Fillingim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Individuals with osteoarthritis (OA) show increased morbidity and mortality. Telomere length, a measure of cellular aging, predicts increased morbidity and mortality. Telomeres shorten with persisting biological and psychosocial stress. Living with chronic OA pain is stressful. Previous research exploring telomere length in people with OA has produced inconsistent results. Considering pain severity may clarify the relationship between OA and telomeres. Objectives: We hypothesized that individuals with high OA chronic pain severity would have shorter telomeres than those with no or low chronic pain severity. Methods: One hundred thirty-six adults, ages 45 to 85 years old, with and without symptomatic knee OA were included in the analysis. Peripheral blood leukocyte telomere length was measured, and demographic, clinical, and functional data were collected. Participants were categorized into 5 pain severity groups based on an additive index of frequency, intensity, time or duration, and total number of pain sites (FITT). Covariates included age, sex, race or ethnicity, study site, and knee pain status. Results: The no or low chronic pain severity group had significantly longer telomeres compared with the high pain severity group, P 5 0.025. A significant chronic pain severity dose response emerged for telomere length, P 5 0.034. The FITT chronic pain severity index was highly correlated with the clinical and functional OA pain measures. However, individual clinical and functional measures were not associated with telomere length. Conclusion: Results demonstrate accelerated cellular aging with high knee OA chronic pain severity and provide evidence for the potential utility of the FITT chronic pain severity index in capturing the biological burden of chronic pain.

Original languageEnglish (US)
Article numbere591
JournalPain Reports
Volume2
Issue number3
DOIs
StatePublished - May 1 2017

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Knee Osteoarthritis
Telomere
Chronic Pain
Pain
Osteoarthritis
Cell Aging
Telomere Shortening
Morbidity
Mortality
Knee
Leukocytes
Demography

Keywords

  • Cellular aging
  • Osteoarthritis
  • Pain severity
  • Stress
  • Telomere length

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Sibille, K. T., Chen, H., Bartley, E. J., Riley, J., Glover, T. L., King, C. D., ... Fillingim, R. B. (2017). Accelerated aging in adults with knee osteoarthritis pain: Consideration for frequency, intensity, time, and total pain sites. Pain Reports, 2(3), [e591]. https://doi.org/10.1097/PR9.0000000000000591

Accelerated aging in adults with knee osteoarthritis pain : Consideration for frequency, intensity, time, and total pain sites. / Sibille, Kimberly T.; Chen, Huaihou; Bartley, Emily J.; Riley, Joseph; Glover, Toni L.; King, Christopher D.; Zhang, Hang; Cruz-Almeida, Yenisel; Goodin, Burel R.; Sotolongo, Adriana; Petrov, Megan; Herbert, Matthew; Bulls, Hailey W.; Edberg, Jeffrey C.; Staud, Roland; Redden, David; Bradley, Laurence A.; Fillingim, Roger B.

In: Pain Reports, Vol. 2, No. 3, e591, 01.05.2017.

Research output: Contribution to journalArticle

Sibille, KT, Chen, H, Bartley, EJ, Riley, J, Glover, TL, King, CD, Zhang, H, Cruz-Almeida, Y, Goodin, BR, Sotolongo, A, Petrov, M, Herbert, M, Bulls, HW, Edberg, JC, Staud, R, Redden, D, Bradley, LA & Fillingim, RB 2017, 'Accelerated aging in adults with knee osteoarthritis pain: Consideration for frequency, intensity, time, and total pain sites', Pain Reports, vol. 2, no. 3, e591. https://doi.org/10.1097/PR9.0000000000000591
Sibille, Kimberly T. ; Chen, Huaihou ; Bartley, Emily J. ; Riley, Joseph ; Glover, Toni L. ; King, Christopher D. ; Zhang, Hang ; Cruz-Almeida, Yenisel ; Goodin, Burel R. ; Sotolongo, Adriana ; Petrov, Megan ; Herbert, Matthew ; Bulls, Hailey W. ; Edberg, Jeffrey C. ; Staud, Roland ; Redden, David ; Bradley, Laurence A. ; Fillingim, Roger B. / Accelerated aging in adults with knee osteoarthritis pain : Consideration for frequency, intensity, time, and total pain sites. In: Pain Reports. 2017 ; Vol. 2, No. 3.
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abstract = "Introduction: Individuals with osteoarthritis (OA) show increased morbidity and mortality. Telomere length, a measure of cellular aging, predicts increased morbidity and mortality. Telomeres shorten with persisting biological and psychosocial stress. Living with chronic OA pain is stressful. Previous research exploring telomere length in people with OA has produced inconsistent results. Considering pain severity may clarify the relationship between OA and telomeres. Objectives: We hypothesized that individuals with high OA chronic pain severity would have shorter telomeres than those with no or low chronic pain severity. Methods: One hundred thirty-six adults, ages 45 to 85 years old, with and without symptomatic knee OA were included in the analysis. Peripheral blood leukocyte telomere length was measured, and demographic, clinical, and functional data were collected. Participants were categorized into 5 pain severity groups based on an additive index of frequency, intensity, time or duration, and total number of pain sites (FITT). Covariates included age, sex, race or ethnicity, study site, and knee pain status. Results: The no or low chronic pain severity group had significantly longer telomeres compared with the high pain severity group, P 5 0.025. A significant chronic pain severity dose response emerged for telomere length, P 5 0.034. The FITT chronic pain severity index was highly correlated with the clinical and functional OA pain measures. However, individual clinical and functional measures were not associated with telomere length. Conclusion: Results demonstrate accelerated cellular aging with high knee OA chronic pain severity and provide evidence for the potential utility of the FITT chronic pain severity index in capturing the biological burden of chronic pain.",
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AU - Riley, Joseph

AU - Glover, Toni L.

AU - King, Christopher D.

AU - Zhang, Hang

AU - Cruz-Almeida, Yenisel

AU - Goodin, Burel R.

AU - Sotolongo, Adriana

AU - Petrov, Megan

AU - Herbert, Matthew

AU - Bulls, Hailey W.

AU - Edberg, Jeffrey C.

AU - Staud, Roland

AU - Redden, David

AU - Bradley, Laurence A.

AU - Fillingim, Roger B.

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N2 - Introduction: Individuals with osteoarthritis (OA) show increased morbidity and mortality. Telomere length, a measure of cellular aging, predicts increased morbidity and mortality. Telomeres shorten with persisting biological and psychosocial stress. Living with chronic OA pain is stressful. Previous research exploring telomere length in people with OA has produced inconsistent results. Considering pain severity may clarify the relationship between OA and telomeres. Objectives: We hypothesized that individuals with high OA chronic pain severity would have shorter telomeres than those with no or low chronic pain severity. Methods: One hundred thirty-six adults, ages 45 to 85 years old, with and without symptomatic knee OA were included in the analysis. Peripheral blood leukocyte telomere length was measured, and demographic, clinical, and functional data were collected. Participants were categorized into 5 pain severity groups based on an additive index of frequency, intensity, time or duration, and total number of pain sites (FITT). Covariates included age, sex, race or ethnicity, study site, and knee pain status. Results: The no or low chronic pain severity group had significantly longer telomeres compared with the high pain severity group, P 5 0.025. A significant chronic pain severity dose response emerged for telomere length, P 5 0.034. The FITT chronic pain severity index was highly correlated with the clinical and functional OA pain measures. However, individual clinical and functional measures were not associated with telomere length. Conclusion: Results demonstrate accelerated cellular aging with high knee OA chronic pain severity and provide evidence for the potential utility of the FITT chronic pain severity index in capturing the biological burden of chronic pain.

AB - Introduction: Individuals with osteoarthritis (OA) show increased morbidity and mortality. Telomere length, a measure of cellular aging, predicts increased morbidity and mortality. Telomeres shorten with persisting biological and psychosocial stress. Living with chronic OA pain is stressful. Previous research exploring telomere length in people with OA has produced inconsistent results. Considering pain severity may clarify the relationship between OA and telomeres. Objectives: We hypothesized that individuals with high OA chronic pain severity would have shorter telomeres than those with no or low chronic pain severity. Methods: One hundred thirty-six adults, ages 45 to 85 years old, with and without symptomatic knee OA were included in the analysis. Peripheral blood leukocyte telomere length was measured, and demographic, clinical, and functional data were collected. Participants were categorized into 5 pain severity groups based on an additive index of frequency, intensity, time or duration, and total number of pain sites (FITT). Covariates included age, sex, race or ethnicity, study site, and knee pain status. Results: The no or low chronic pain severity group had significantly longer telomeres compared with the high pain severity group, P 5 0.025. A significant chronic pain severity dose response emerged for telomere length, P 5 0.034. The FITT chronic pain severity index was highly correlated with the clinical and functional OA pain measures. However, individual clinical and functional measures were not associated with telomere length. Conclusion: Results demonstrate accelerated cellular aging with high knee OA chronic pain severity and provide evidence for the potential utility of the FITT chronic pain severity index in capturing the biological burden of chronic pain.

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KW - Osteoarthritis

KW - Pain severity

KW - Stress

KW - Telomere length

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