Absence of age-resistance in neonatally thymectomised chickens as evidence for cell-mediated immune surveillance in Marek's disease

J. M. Sharma, R. L. Witter, H. G. Purchase

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

MAREK'S disease virus (MDV) of chickens induces lymphomas and other lymphoproliferative changes, which, depending on the virulence of the strain used, may terminate in paralysis and death. Chickens genetically selected for resistance, however, are refractory to clinical MD and most chickens that are fully susceptible when young develop resistance as they become older. Resistance acquired with age is expressed through lesion regression1,2. Our studies with genetic and age resistance established that humoral immunity did not play a major role in either type of resistance3,4 and now we present evidence that the thymus-dependent immune system is of principal importance in the natural resistance of old chickens.

Original languageEnglish (US)
Pages (from-to)477-479
Number of pages3
JournalNature
Volume253
Issue number5491
DOIs
StatePublished - 1975
Externally publishedYes

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Marek Disease
Chickens
Virus Diseases
Humoral Immunity
Innate Immunity
Paralysis
Thymus Gland
Virulence
Immune System
Lymphoma

ASJC Scopus subject areas

  • General

Cite this

Absence of age-resistance in neonatally thymectomised chickens as evidence for cell-mediated immune surveillance in Marek's disease. / Sharma, J. M.; Witter, R. L.; Purchase, H. G.

In: Nature, Vol. 253, No. 5491, 1975, p. 477-479.

Research output: Contribution to journalArticle

Sharma, J. M. ; Witter, R. L. ; Purchase, H. G. / Absence of age-resistance in neonatally thymectomised chickens as evidence for cell-mediated immune surveillance in Marek's disease. In: Nature. 1975 ; Vol. 253, No. 5491. pp. 477-479.
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