ABO incompatible renal transplantation in an HIV-seropositive patient

Maya Campara, Patricia West-Thielke, James Thielke, Thuy Ommert, Jose Oberholzer, Enrico Benedetti, Bruce Kaplan

    Research output: Contribution to journalArticle

    4 Scopus citations

    Abstract

    To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.

    Original languageEnglish (US)
    Pages (from-to)176-178
    Number of pages3
    JournalTransplantation
    Volume86
    Issue number1
    DOIs
    StatePublished - Jul 15 2008

    Keywords

    • ABO incompatibility
    • HIV
    • Renal transplant

    ASJC Scopus subject areas

    • Transplantation

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  • Cite this

    Campara, M., West-Thielke, P., Thielke, J., Ommert, T., Oberholzer, J., Benedetti, E., & Kaplan, B. (2008). ABO incompatible renal transplantation in an HIV-seropositive patient. Transplantation, 86(1), 176-178. https://doi.org/10.1097/TP.0b013e31817cf403