ABO incompatible renal transplantation in an HIV-seropositive patient

Maya Campara; Patricia West-Thielke; James Thielke; Thuy Ommert; Jose Oberholzer; Enrico Benedetti; Bruce Kaplan

doi:10.1097/TP.0b013e31817cf403

ABO incompatible renal transplantation in an HIV-seropositive patient

Maya Campara, Patricia West-Thielke, James Thielke, Thuy Ommert, Jose Oberholzer, Enrico Benedetti, Bruce Kaplan

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.

Original language	English (US)
Pages (from-to)	176-178
Number of pages	3
Journal	Transplantation
Volume	86
Issue number	1
DOIs	https://doi.org/10.1097/TP.0b013e31817cf403
State	Published - Jul 15 2008
Externally published	Yes

Keywords

ABO incompatibility
HIV
Renal transplant

ASJC Scopus subject areas

Transplantation

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10.1097/TP.0b013e31817cf403

Cite this

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title = "ABO incompatible renal transplantation in an HIV-seropositive patient",

abstract = "To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.",

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AU - Campara, Maya

AU - West-Thielke, Patricia

AU - Thielke, James

AU - Ommert, Thuy

AU - Oberholzer, Jose

AU - Benedetti, Enrico

AU - Kaplan, Bruce

PY - 2008/7/15

Y1 - 2008/7/15

N2 - To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.

AB - To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.

KW - ABO incompatibility

KW - HIV

KW - Renal transplant

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ABO incompatible renal transplantation in an HIV-seropositive patient

Abstract

Keywords

ASJC Scopus subject areas

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