ABO incompatible renal transplantation in an HIV-seropositive patient

Maya Campara, Patricia West-Thielke, James Thielke, Thuy Ommert, Jose Oberholzer, Enrico Benedetti, Bruce Kaplan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalTransplantation
Volume86
Issue number1
DOIs
StatePublished - Jul 15 2008
Externally publishedYes

Fingerprint

Blood Group Antigens
Kidney Transplantation
Adrenal Cortex Hormones
Maintenance
HIV
Mycophenolic Acid
Unrelated Donors
Plasmapheresis
Interleukin-2 Receptors
Intravenous Immunoglobulins
Tacrolimus
CD4 Lymphocyte Count
Spouses
African Americans
Immunosuppression
Chronic Kidney Failure
Creatinine
Transplants
Biopsy
Antibodies

Keywords

  • ABO incompatibility
  • HIV
  • Renal transplant

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Campara, M., West-Thielke, P., Thielke, J., Ommert, T., Oberholzer, J., Benedetti, E., & Kaplan, B. (2008). ABO incompatible renal transplantation in an HIV-seropositive patient. Transplantation, 86(1), 176-178. https://doi.org/10.1097/TP.0b013e31817cf403

ABO incompatible renal transplantation in an HIV-seropositive patient. / Campara, Maya; West-Thielke, Patricia; Thielke, James; Ommert, Thuy; Oberholzer, Jose; Benedetti, Enrico; Kaplan, Bruce.

In: Transplantation, Vol. 86, No. 1, 15.07.2008, p. 176-178.

Research output: Contribution to journalArticle

Campara, M, West-Thielke, P, Thielke, J, Ommert, T, Oberholzer, J, Benedetti, E & Kaplan, B 2008, 'ABO incompatible renal transplantation in an HIV-seropositive patient', Transplantation, vol. 86, no. 1, pp. 176-178. https://doi.org/10.1097/TP.0b013e31817cf403
Campara M, West-Thielke P, Thielke J, Ommert T, Oberholzer J, Benedetti E et al. ABO incompatible renal transplantation in an HIV-seropositive patient. Transplantation. 2008 Jul 15;86(1):176-178. https://doi.org/10.1097/TP.0b013e31817cf403
Campara, Maya ; West-Thielke, Patricia ; Thielke, James ; Ommert, Thuy ; Oberholzer, Jose ; Benedetti, Enrico ; Kaplan, Bruce. / ABO incompatible renal transplantation in an HIV-seropositive patient. In: Transplantation. 2008 ; Vol. 86, No. 1. pp. 176-178.
@article{3e79071f16334a3483dbaa33ae534569,
title = "ABO incompatible renal transplantation in an HIV-seropositive patient",
abstract = "To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.",
keywords = "ABO incompatibility, HIV, Renal transplant",
author = "Maya Campara and Patricia West-Thielke and James Thielke and Thuy Ommert and Jose Oberholzer and Enrico Benedetti and Bruce Kaplan",
year = "2008",
month = "7",
day = "15",
doi = "10.1097/TP.0b013e31817cf403",
language = "English (US)",
volume = "86",
pages = "176--178",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - ABO incompatible renal transplantation in an HIV-seropositive patient

AU - Campara, Maya

AU - West-Thielke, Patricia

AU - Thielke, James

AU - Ommert, Thuy

AU - Oberholzer, Jose

AU - Benedetti, Enrico

AU - Kaplan, Bruce

PY - 2008/7/15

Y1 - 2008/7/15

N2 - To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.

AB - To date, there have been no reports of successful ABO blood group incompatible renal transplantation in HIV patients. We describe a case of a 47-year-old African American man with end-stage renal disease secondary to HIV-induced nephropathy who underwent a live unrelated (spouse) donor ABO blood group incompatible transplant using an intravenous immunoglobulin/plasmapheresis preconditioning regimen with interleukin-2 receptor antagonist induction along with tacrolimus and mycophenolate mofetil maintenance. The postoperative course was complicated by two acute cellular rejection (Banff Ia) episodes that were successfully managed with corticosteroid boluses and the addition of corticosteroids to maintenance immunosuppression. Antibody-mediated rejection was not observed on biopsy. The patient reached a serum creatinine nadir of 2.0 mg/dL on postoperative day 20, which has now been maintained for 170 days. His current CD4 count was 410 cells/μL.

KW - ABO incompatibility

KW - HIV

KW - Renal transplant

UR - http://www.scopus.com/inward/record.url?scp=49849099938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49849099938&partnerID=8YFLogxK

U2 - 10.1097/TP.0b013e31817cf403

DO - 10.1097/TP.0b013e31817cf403

M3 - Article

C2 - 18622297

AN - SCOPUS:49849099938

VL - 86

SP - 176

EP - 178

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 1

ER -