@inproceedings{1d640232d2244fc8bde6005cd27b30e2,
title = "Abnormal ventricular development in preterm neonates with visually normal MRIs",
abstract = "Children born preterm are at risk for a wide range of neurocognitive and neurobehavioral disorders. Some of these may stem from early brain abnormalities at the neonatal age. Hence, a precise characterization of neonatal neuroanatomy may help inform treatment strategies. In particular, the ventricles are often enlarged in neurocognitive disorders, due to atrophy of surrounding tissues. Here we present a new pipeline for the detection of morphological and relative pose differences in the ventricles of premature neonates compared to controls. To this end, we use a new hyperbolic Ricci flow based mapping of the ventricular surfaces of each subjects to the Poincar{\'e} disk. Resulting surfaces are then registered to a template, and a between group comparison is performed using multivariate tensor-based morphometry. We also statistically compare the relative pose of the ventricles within the brain between the two groups, by performing a Procrustes alignment between each subject's ventricles and an average shape. For both types of analyses, differences were found in the left ventricles between the two groups.",
keywords = "brain, image analysis, magnetic resonance imaging, prematurity",
author = "Jie Shi and Yalin Wang and Yi Lao and Rafael Ceschin and Liang Mi and Nelson, {Marvin D.} and Ashok Panigrahy and Natasha Lepor{\'e}",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; 11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015 ; Conference date: 17-11-2015 Through 19-11-2015",
year = "2015",
doi = "10.1117/12.2213297",
language = "English (US)",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Garcia-Arteaga, {Juan D.} and Jorge Brieva and Natasha Lepore and Eduardo Romero",
booktitle = "11th International Symposium on Medical Information Processing and Analysis",
}