Abnormal ventricular development in preterm neonates with visually normal MRIs

Jie Shi, Yalin Wang, Yi Lao, Rafael Ceschin, Liang Mi, Marvin D. Nelson, Ashok Panigrahy, Natasha Leporé

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Children born preterm are at risk for a wide range of neurocognitive and neurobehavioral disorders. Some of these may stem from early brain abnormalities at the neonatal age. Hence, a precise characterization of neonatal neuroanatomy may help inform treatment strategies. In particular, the ventricles are often enlarged in neurocognitive disorders, due to atrophy of surrounding tissues. Here we present a new pipeline for the detection of morphological and relative pose differences in the ventricles of premature neonates compared to controls. To this end, we use a new hyperbolic Ricci flow based mapping of the ventricular surfaces of each subjects to the Poincaré disk. Resulting surfaces are then registered to a template, and a between group comparison is performed using multivariate tensor-based morphometry. We also statistically compare the relative pose of the ventricles within the brain between the two groups, by performing a Procrustes alignment between each subject's ventricles and an average shape. For both types of analyses, differences were found in the left ventricles between the two groups.

Original languageEnglish (US)
Title of host publication11th International Symposium on Medical Information Processing and Analysis
EditorsJuan D. Garcia-Arteaga, Jorge Brieva, Natasha Lepore, Eduardo Romero
PublisherSPIE
ISBN (Electronic)9781628419160
DOIs
StatePublished - 2015
Event11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015 - Cuenca, Ecuador
Duration: Nov 17 2015Nov 19 2015

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9681
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

Other11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015
CountryEcuador
CityCuenca
Period11/17/1511/19/15

Keywords

  • brain
  • image analysis
  • magnetic resonance imaging
  • prematurity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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