Abstract
Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R§ssup§2§esup§ = 0.13, β = -1.7; p = 0.006; R§ssup§2§esup§ = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R§ssup§2§ esup§ = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents.
| Original language | English (US) |
|---|---|
| Article number | 72 |
| Journal | Diabetology and Metabolic Syndrome |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2013 |
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Keywords
- Abdominal obesity
- Insulin resistance
- Latino adolescents
- Metabolic syndrome
- Oxidized LDL
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents. / Ryder, Justin R.; Vega-Lopez, Sonia; Djedjos, Constantine S.; Shaibi, Gabriel.
In: Diabetology and Metabolic Syndrome, Vol. 5, No. 1, 72, 2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents
AU - Ryder, Justin R.
AU - Vega-Lopez, Sonia
AU - Djedjos, Constantine S.
AU - Shaibi, Gabriel
PY - 2013
Y1 - 2013
N2 - Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R§ssup§2§esup§ = 0.13, β = -1.7; p = 0.006; R§ssup§2§esup§ = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R§ssup§2§ esup§ = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents.
AB - Abdominal obesity and insulin resistance (IR) place youth at higher risk for premature cardiovascular disease (CVD), but the underlying mechanisms are not clear. In adults, abdominal obesity and IR contribute to the oxidation of low-density lipoprotein (LDL). Whether similar mechanisms are operational in Latino adolescents is unknown. Therefore, we determined whether IR and abdominal adiposity are associated with higher oxLDL concentrations in Latino adolescents. Data from 123 Latino adolescents (16.3 ± 2.5 years; female = 74) were used for the present analysis. Participants were assessed for waist circumference, fasting serum oxLDL, and insulin sensitivity by the whole body insulin sensitivity index. In separate linear regression models adjusting for age and sex, both waist circumference and insulin sensitivity were significant predictors of oxLDL (β = 1.9; p = 0.002; R§ssup§2§esup§ = 0.13, β = -1.7; p = 0.006; R§ssup§2§esup§ = 0.11, respectively). When insulin sensitivity and waist circumference were included in the same model, both remained independent predictors of oxLDL (β = 1.7; p = 0.016 and, β = -1.5; p = 0.055, respectively; R§ssup§2§ esup§ = 0.16). These results suggest that insulin resistance and abdominal adiposity are associated with higher levels of LDL oxidation which may be a mechanism contributing to increased CVD risk in Latino adolescents.
KW - Abdominal obesity
KW - Insulin resistance
KW - Latino adolescents
KW - Metabolic syndrome
KW - Oxidized LDL
UR - http://www.scopus.com/inward/record.url?scp=84887533052&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887533052&partnerID=8YFLogxK
U2 - 10.1186/1758-5996-5-72
DO - 10.1186/1758-5996-5-72
M3 - Article
VL - 5
JO - Diabetology and Metabolic Syndrome
JF - Diabetology and Metabolic Syndrome
SN - 1758-5996
IS - 1
M1 - 72
ER -