Goal: We propose a novel wireless fully passive neural recording device for unobtrusive neuropotential monitoring. Previous work demonstrated the feasibility of monitoring emulated brain signals in a wireless fully passive manner. In this paper, we propose a novel realistic recorder that is significantly smaller and much more sensitive. Methods: The proposed recorder utilizes a highly efficient microwave backscattering method and operates without any formal power supply or regulating elements. Also, no intracranial wires or cables are required. In-vitro testing is performed inside a four-layer head phantom (skin, bone, gray matter, and white matter). Results: Compared to our former implementation, the neural recorder proposed in this study has the following improved features: 1) 59% smaller footprint, 2) up to 20-dB improvement in neuropotential detection sensitivity, and 3) encapsulation in biocompatible polymer. Conclusion: For the first time, temporal emulated neuropotentials as low as 63 μVpp can be detected in a wireless fully passive manner. Remarkably, the highsensitivity achieved in this study implies reading of most neural signals generated by the human brain. Significance: The proposed recorder brings forward transformational possibilities in wireless fully passive neural detection for a very wide range of applications (e.g., epilepsy, Alzheimer's, mental disorders, etc.).

Original languageEnglish (US)
Article number458583
Pages (from-to)131-137
Number of pages7
JournalIEEE Transactions on Biomedical Engineering
Issue number1
StatePublished - Jan 2016


  • Antiparallel diode pair
  • Biocompatibility
  • Biomedical telemetry
  • Brain implant
  • Miniaturization
  • Neurosensing
  • Passive circuits
  • Subharmonic mixer

ASJC Scopus subject areas

  • Biomedical Engineering

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