A vibrating probe thermal biochemical sensor

Bruce C. Towe; Eric J. Guilbeau

doi:10.1016/0956-5663(96)88411-9

A vibrating probe thermal biochemical sensor

Bruce C. Towe, Eric J. Guilbeau

Biological and Health Systems Engineering, School of (IAFSE-BHSE)

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Rapid vibration of small enzyme-thermopile biochemical sensors in solution has been observed to substantially improve their thermal noise rejection. Millimeter-order 20 Hz vibratory excursions of a thermal biosensor by a piezoelectric bender element were found to be effective in eliminating the need for temperature controlled dewars, flow streams, or special thermal environments ordinarily required to operate these sensors. Vibrated thermopiles have been made into biochemical sensors by attaching thin membrane hollow fibers to the thermopile sensing region and perfusing the lumen of the fiber with small quantities of an enzyme solution. This process can give the biosensor an extended lifetime by allowing easy replacement of the enzyme. Vibrated enzyme-thermopile biochemical sensors can be realized in a convenient and compact probe-type configuration that is directly immersible into a test solution.

Original language	English (US)
Pages (from-to)	247-252
Number of pages	6
Journal	Biosensors and Bioelectronics
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0956-5663(96)88411-9
State	Published - 1996

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

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10.1016/0956-5663(96)88411-9

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title = "A vibrating probe thermal biochemical sensor",

abstract = "Rapid vibration of small enzyme-thermopile biochemical sensors in solution has been observed to substantially improve their thermal noise rejection. Millimeter-order 20 Hz vibratory excursions of a thermal biosensor by a piezoelectric bender element were found to be effective in eliminating the need for temperature controlled dewars, flow streams, or special thermal environments ordinarily required to operate these sensors. Vibrated thermopiles have been made into biochemical sensors by attaching thin membrane hollow fibers to the thermopile sensing region and perfusing the lumen of the fiber with small quantities of an enzyme solution. This process can give the biosensor an extended lifetime by allowing easy replacement of the enzyme. Vibrated enzyme-thermopile biochemical sensors can be realized in a convenient and compact probe-type configuration that is directly immersible into a test solution.",

author = "Towe, {Bruce C.} and Guilbeau, {Eric J.}",

note = "Funding Information: This work was supported by grants from the Whitaker Foundation, the Arizona Disease Control Commission, the NIH Biomedical Research Incentives Program, and the Arizona State University. The work was performed in the Bioengineering laboratories of Arizona State University. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1996",

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T1 - A vibrating probe thermal biochemical sensor

AU - Towe, Bruce C.

AU - Guilbeau, Eric J.

N1 - Funding Information: This work was supported by grants from the Whitaker Foundation, the Arizona Disease Control Commission, the NIH Biomedical Research Incentives Program, and the Arizona State University. The work was performed in the Bioengineering laboratories of Arizona State University. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1996

Y1 - 1996

N2 - Rapid vibration of small enzyme-thermopile biochemical sensors in solution has been observed to substantially improve their thermal noise rejection. Millimeter-order 20 Hz vibratory excursions of a thermal biosensor by a piezoelectric bender element were found to be effective in eliminating the need for temperature controlled dewars, flow streams, or special thermal environments ordinarily required to operate these sensors. Vibrated thermopiles have been made into biochemical sensors by attaching thin membrane hollow fibers to the thermopile sensing region and perfusing the lumen of the fiber with small quantities of an enzyme solution. This process can give the biosensor an extended lifetime by allowing easy replacement of the enzyme. Vibrated enzyme-thermopile biochemical sensors can be realized in a convenient and compact probe-type configuration that is directly immersible into a test solution.

AB - Rapid vibration of small enzyme-thermopile biochemical sensors in solution has been observed to substantially improve their thermal noise rejection. Millimeter-order 20 Hz vibratory excursions of a thermal biosensor by a piezoelectric bender element were found to be effective in eliminating the need for temperature controlled dewars, flow streams, or special thermal environments ordinarily required to operate these sensors. Vibrated thermopiles have been made into biochemical sensors by attaching thin membrane hollow fibers to the thermopile sensing region and perfusing the lumen of the fiber with small quantities of an enzyme solution. This process can give the biosensor an extended lifetime by allowing easy replacement of the enzyme. Vibrated enzyme-thermopile biochemical sensors can be realized in a convenient and compact probe-type configuration that is directly immersible into a test solution.

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A vibrating probe thermal biochemical sensor

Abstract

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