A universal biosensing platform based on optical micro-ring resonators

A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, B. E. Little

Research output: Contribution to journalArticle

183 Scopus citations

Abstract

The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
JournalBiosensors and Bioelectronics
Volume23
Issue number7
DOIs
StatePublished - Feb 28 2008
Externally publishedYes

Keywords

  • Antibody
  • Antigen
  • Bacteria
  • Biosensor
  • IgG
  • IgM
  • Label-free quantitative detection
  • Micro-ring resonators
  • Nucleic acid
  • Optical resonators
  • Whole cell detection

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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  • Cite this

    Ramachandran, A., Wang, S., Clarke, J., Ja, S. J., Goad, D., Wald, L., Flood, E. M., Knobbe, E., Hryniewicz, J. V., Chu, S. T., Gill, D., Chen, W., King, O., & Little, B. E. (2008). A universal biosensing platform based on optical micro-ring resonators. Biosensors and Bioelectronics, 23(7), 939-944. https://doi.org/10.1016/j.bios.2007.09.007