A universal biosensing platform based on optical micro-ring resonators

A. Ramachandran; S. Wang; J. Clarke; S. J. Ja; D. Goad; L. Wald; E. M. Flood; E. Knobbe; J. V. Hryniewicz; S. T. Chu; D. Gill; W. Chen; O. King; B. E. Little

doi:10.1016/j.bios.2007.09.007

A universal biosensing platform based on optical micro-ring resonators

A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, B. E. Little

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids.

Original language	English (US)
Pages (from-to)	939-944
Number of pages	6
Journal	Biosensors and Bioelectronics
Volume	23
Issue number	7
DOIs	https://doi.org/10.1016/j.bios.2007.09.007
State	Published - Feb 28 2008
Externally published	Yes

Keywords

Antibody
Antigen
Bacteria
Biosensor
IgG
IgM
Label-free quantitative detection
Micro-ring resonators
Nucleic acid
Optical resonators
Whole cell detection

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

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10.1016/j.bios.2007.09.007

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title = "A universal biosensing platform based on optical micro-ring resonators",

abstract = "The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids.",

keywords = "Antibody, Antigen, Bacteria, Biosensor, IgG, IgM, Label-free quantitative detection, Micro-ring resonators, Nucleic acid, Optical resonators, Whole cell detection",

author = "A. Ramachandran and S. Wang and J. Clarke and Ja, {S. J.} and D. Goad and L. Wald and Flood, {E. M.} and E. Knobbe and Hryniewicz, {J. V.} and Chu, {S. T.} and D. Gill and W. Chen and O. King and Little, {B. E.}",

note = "Funding Information: This research was partially supported by funding from DARPA (Contract W81XWH-04-C-0139) and Oklahoma Center for the Advancement of Science and Technology (OARS award AR 03(2)-068).",

year = "2008",

month = feb,

day = "28",

doi = "10.1016/j.bios.2007.09.007",

language = "English (US)",

volume = "23",

pages = "939--944",

journal = "Biosensors and Bioelectronics",

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T1 - A universal biosensing platform based on optical micro-ring resonators

AU - Ramachandran, A.

AU - Wang, S.

AU - Clarke, J.

AU - Ja, S. J.

AU - Goad, D.

AU - Wald, L.

AU - Flood, E. M.

AU - Knobbe, E.

AU - Hryniewicz, J. V.

AU - Chu, S. T.

AU - Gill, D.

AU - Chen, W.

AU - King, O.

AU - Little, B. E.

N1 - Funding Information: This research was partially supported by funding from DARPA (Contract W81XWH-04-C-0139) and Oklahoma Center for the Advancement of Science and Technology (OARS award AR 03(2)-068).

PY - 2008/2/28

Y1 - 2008/2/28

N2 - The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids.

AB - The use of optical micro-ring resonators as a platform for quantitative and qualitative biosensing applications was explored. Vertically coupled, high refractive index micro-ring resonators, used as sensing elements, were fabricated on silicon chips by photolithographic techniques. An optical reader system consisting of a near-infrared broad band light source and an optical spectrum analyzer were employed for data acquisition. Micro-ring resonator surfaces were modified with specific target receptors, including antibodies and single-stranded DNA oligonucleotides. The system was successfully used for label-free, specific, and rapid detection of whole bacterial cells, proteins and nucleic acids.

KW - Antibody

KW - Antigen

KW - Bacteria

KW - Biosensor

KW - IgG

KW - IgM

KW - Label-free quantitative detection

KW - Micro-ring resonators

KW - Nucleic acid

KW - Optical resonators

KW - Whole cell detection

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M3 - Article

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AN - SCOPUS:38749109658

SN - 0956-5663

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JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

IS - 7

ER -

A universal biosensing platform based on optical micro-ring resonators

Abstract

Keywords

ASJC Scopus subject areas

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