A two-strain tuberculosis model with age of infection

Z. Feng, M. Iannelli, F. A. Milner

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Long periods of latency and the emergence of antibiotic resistance due to incomplete treatment are very important features of tuberculosis (TB) dynamics. Previous studies of two-strain TB have been performed by ODE models. In this article, we formulate a two-strain TB model with an arbitrarily distributed delay in the latent stage of individuals infected with the drug-sensitive strain and look at the effects of variable periods of latency on the disease dynamics.

Original languageEnglish (US)
Pages (from-to)1634-1656
Number of pages23
JournalSIAM Journal on Applied Mathematics
Volume62
Issue number5
DOIs
StatePublished - May 1 2002
Externally publishedYes

Keywords

  • Distributed delays
  • Mathematical models
  • Stability
  • Tuberculosis

ASJC Scopus subject areas

  • Applied Mathematics

Fingerprint Dive into the research topics of 'A two-strain tuberculosis model with age of infection'. Together they form a unique fingerprint.

  • Cite this