A two-strain tuberculosis model with age of infection

Z. Feng; M. Iannelli; F. A. Milner

doi:10.1137/S003613990038205X

A two-strain tuberculosis model with age of infection

Z. Feng, M. Iannelli, F. A. Milner

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Long periods of latency and the emergence of antibiotic resistance due to incomplete treatment are very important features of tuberculosis (TB) dynamics. Previous studies of two-strain TB have been performed by ODE models. In this article, we formulate a two-strain TB model with an arbitrarily distributed delay in the latent stage of individuals infected with the drug-sensitive strain and look at the effects of variable periods of latency on the disease dynamics.

Original language	English (US)
Pages (from-to)	1634-1656
Number of pages	23
Journal	SIAM Journal on Applied Mathematics
Volume	62
Issue number	5
DOIs	https://doi.org/10.1137/S003613990038205X
State	Published - May 2002
Externally published	Yes

Keywords

Distributed delays
Mathematical models
Stability
Tuberculosis

ASJC Scopus subject areas

Applied Mathematics

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10.1137/S003613990038205X

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abstract = "Long periods of latency and the emergence of antibiotic resistance due to incomplete treatment are very important features of tuberculosis (TB) dynamics. Previous studies of two-strain TB have been performed by ODE models. In this article, we formulate a two-strain TB model with an arbitrarily distributed delay in the latent stage of individuals infected with the drug-sensitive strain and look at the effects of variable periods of latency on the disease dynamics.",

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KW - Distributed delays

KW - Mathematical models

KW - Stability

KW - Tuberculosis

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A two-strain tuberculosis model with age of infection

Abstract

Keywords

ASJC Scopus subject areas

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