A two-strain tuberculosis model with age of infection

Z. Feng, M. Iannelli, F. A. Milner

Research output: Contribution to journalArticle

75 Scopus citations


Long periods of latency and the emergence of antibiotic resistance due to incomplete treatment are very important features of tuberculosis (TB) dynamics. Previous studies of two-strain TB have been performed by ODE models. In this article, we formulate a two-strain TB model with an arbitrarily distributed delay in the latent stage of individuals infected with the drug-sensitive strain and look at the effects of variable periods of latency on the disease dynamics.

Original languageEnglish (US)
Pages (from-to)1634-1656
Number of pages23
JournalSIAM Journal on Applied Mathematics
Issue number5
StatePublished - May 1 2002
Externally publishedYes


  • Distributed delays
  • Mathematical models
  • Stability
  • Tuberculosis

ASJC Scopus subject areas

  • Applied Mathematics

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