A two-strain tuberculosis model with age of infection

Z. Feng, M. Iannelli, Fabio Milner

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Long periods of latency and the emergence of antibiotic resistance due to incomplete treatment are very important features of tuberculosis (TB) dynamics. Previous studies of two-strain TB have been performed by ODE models. In this article, we formulate a two-strain TB model with an arbitrarily distributed delay in the latent stage of individuals infected with the drug-sensitive strain and look at the effects of variable periods of latency on the disease dynamics.

Original languageEnglish (US)
Pages (from-to)1634-1656
Number of pages23
JournalSIAM Journal on Applied Mathematics
Volume62
Issue number5
DOIs
StatePublished - May 2002
Externally publishedYes

Fingerprint

Tuberculosis
Infection
Latency
Distributed Delay
Antibiotics
Drugs
Model

Keywords

  • Distributed delays
  • Mathematical models
  • Stability
  • Tuberculosis

ASJC Scopus subject areas

  • Mathematics(all)
  • Applied Mathematics

Cite this

A two-strain tuberculosis model with age of infection. / Feng, Z.; Iannelli, M.; Milner, Fabio.

In: SIAM Journal on Applied Mathematics, Vol. 62, No. 5, 05.2002, p. 1634-1656.

Research output: Contribution to journalArticle

Feng, Z. ; Iannelli, M. ; Milner, Fabio. / A two-strain tuberculosis model with age of infection. In: SIAM Journal on Applied Mathematics. 2002 ; Vol. 62, No. 5. pp. 1634-1656.
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