Abstract
A new turn-off fluorescent substrate for horseradish peroxidase is introduced, termed clics, which enhances the sensitivity of commercial enzyme-linked immunosorbant assays (ELISA) by 32-fold and detects chlamydial infections in patients. Clics are cost-effective, stable, and can be easily incorporated in commercial ELISA kits, and therefore should have a great impact in the fields of medicine and biology.
Original language | English (US) |
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Pages (from-to) | 206-210 |
Number of pages | 5 |
Journal | Journal of Polymer Science, Part A: Polymer Chemistry |
Volume | 53 |
Issue number | 2 |
DOIs | |
State | Published - Jan 15 2015 |
Externally published | Yes |
Keywords
- ELISA
- biomaterials
- chlamydia
- cyanine
- diagnostics
- enzymes
- liposome
- nanotechnology
- ultrasensitive
ASJC Scopus subject areas
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry