A translational behavioral model of mood-based impulsivity: Implications for substance abuse

Cassandra D. Gipson; Joshua S. Beckmann; Zack W. Adams; Julie A. Marusich; Travis O. Nesland; Justin R. Yates; Thomas H. Kelly; Michael T. Bardo

doi:10.1016/j.drugalcdep.2011.09.014

A translational behavioral model of mood-based impulsivity: Implications for substance abuse

Cassandra D. Gipson, Joshua S. Beckmann, Zack W. Adams, Julie A. Marusich, Travis O. Nesland, Justin R. Yates, Thomas H. Kelly, Michael T. Bardo

Psychology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.

Original language	English (US)
Pages (from-to)	93-99
Number of pages	7
Journal	Drug and alcohol dependence
Volume	122
Issue number	1-2
DOIs	https://doi.org/10.1016/j.drugalcdep.2011.09.014
State	Published - Apr 1 2012

Keywords

Amphetamine
Impulsivity
Negative urgency
Self-administration
Substance abuse
Translational research

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/j.drugalcdep.2011.09.014

Cite this

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title = "A translational behavioral model of mood-based impulsivity: Implications for substance abuse",

abstract = "Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.",

keywords = "Amphetamine, Impulsivity, Negative urgency, Self-administration, Substance abuse, Translational research",

author = "Gipson, {Cassandra D.} and Beckmann, {Joshua S.} and Adams, {Zack W.} and Marusich, {Julie A.} and Nesland, {Travis O.} and Yates, {Justin R.} and Kelly, {Thomas H.} and Bardo, {Michael T.}",

note = "Funding Information: This work was supported by NIH Grants F31 DA028018 , P50 DA05312 , and T32 DA007304 . Additionally, this work was supported, in part, by the University of Kentucky Center on Drug and Alcohol Research, the American Psychological Association Science Directorate Dissertation Research Award, the American Psychological Association Division 28 Outstanding Dissertation Award, and the Dissertation Fellowship from the Graduate School at the University of Kentucky. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2012",

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doi = "10.1016/j.drugalcdep.2011.09.014",

language = "English (US)",

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AU - Gipson, Cassandra D.

AU - Beckmann, Joshua S.

AU - Adams, Zack W.

AU - Marusich, Julie A.

AU - Nesland, Travis O.

AU - Yates, Justin R.

AU - Kelly, Thomas H.

AU - Bardo, Michael T.

N1 - Funding Information: This work was supported by NIH Grants F31 DA028018 , P50 DA05312 , and T32 DA007304 . Additionally, this work was supported, in part, by the University of Kentucky Center on Drug and Alcohol Research, the American Psychological Association Science Directorate Dissertation Research Award, the American Psychological Association Division 28 Outstanding Dissertation Award, and the Dissertation Fellowship from the Graduate School at the University of Kentucky. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.

AB - Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.

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A translational behavioral model of mood-based impulsivity: Implications for substance abuse

Abstract

Keywords

ASJC Scopus subject areas

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