A translational behavioral model of mood-based impulsivity: Implications for substance abuse

Cassandra D. Gipson, Joshua S. Beckmann, Zack W. Adams, Julie A. Marusich, Travis O. Nesland, Justin R. Yates, Thomas H. Kelly, Michael T. Bardo

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalDrug and alcohol dependence
Volume122
Issue number1-2
DOIs
StatePublished - Apr 1 2012

Keywords

  • Amphetamine
  • Impulsivity
  • Negative urgency
  • Self-administration
  • Substance abuse
  • Translational research

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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    Gipson, C. D., Beckmann, J. S., Adams, Z. W., Marusich, J. A., Nesland, T. O., Yates, J. R., Kelly, T. H., & Bardo, M. T. (2012). A translational behavioral model of mood-based impulsivity: Implications for substance abuse. Drug and alcohol dependence, 122(1-2), 93-99. https://doi.org/10.1016/j.drugalcdep.2011.09.014