A translational behavioral model of mood-based impulsivity: Implications for substance abuse

Cassandra Gipson-Reichardt, Joshua S. Beckmann, Zack W. Adams, Julie A. Marusich, Travis O. Nesland, Justin R. Yates, Thomas H. Kelly, Michael T. Bardo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Laboratory tasks that measure various facets of impulsivity derived from self-report questionnaires are important for elucidating the behavioral consequences of impulsivity in humans and for back-translating these facets to non-human species. Negative urgency, or mood-based rash action, is a self-report facet of impulsivity linked to problem substance use; however, a valid behavioral task is lacking. Methods: The current studies were designed to bridge self-report questionnaire and behavioral measures of negative urgency in humans and to determine if this could be back-translated to rats. Results: Humans scoring high in negative urgency showed greater behavioral responding and increased frustration following unexpected reward omission on a monetary-based task compared to subjects low in negative urgency. Rats also showed elevated responding for either sucrose pellets or intravenous amphetamine following unexpected reward omission. Conclusion: These results suggest that impulsive behavior engendered by unexpected reward omission may represent a valid behavioral model of negative urgency linked to substance abuse.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalDrug and Alcohol Dependence
Volume122
Issue number1-2
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

Fingerprint

Impulsive Behavior
Substance-Related Disorders
Rats
Reward
Self Report
Amphetamine
Sucrose
Frustration
Exanthema
Surveys and Questionnaires

Keywords

  • Amphetamine
  • Impulsivity
  • Negative urgency
  • Self-administration
  • Substance abuse
  • Translational research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Toxicology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Gipson-Reichardt, C., Beckmann, J. S., Adams, Z. W., Marusich, J. A., Nesland, T. O., Yates, J. R., ... Bardo, M. T. (2012). A translational behavioral model of mood-based impulsivity: Implications for substance abuse. Drug and Alcohol Dependence, 122(1-2), 93-99. https://doi.org/10.1016/j.drugalcdep.2011.09.014

A translational behavioral model of mood-based impulsivity : Implications for substance abuse. / Gipson-Reichardt, Cassandra; Beckmann, Joshua S.; Adams, Zack W.; Marusich, Julie A.; Nesland, Travis O.; Yates, Justin R.; Kelly, Thomas H.; Bardo, Michael T.

In: Drug and Alcohol Dependence, Vol. 122, No. 1-2, 01.04.2012, p. 93-99.

Research output: Contribution to journalArticle

Gipson-Reichardt, C, Beckmann, JS, Adams, ZW, Marusich, JA, Nesland, TO, Yates, JR, Kelly, TH & Bardo, MT 2012, 'A translational behavioral model of mood-based impulsivity: Implications for substance abuse', Drug and Alcohol Dependence, vol. 122, no. 1-2, pp. 93-99. https://doi.org/10.1016/j.drugalcdep.2011.09.014
Gipson-Reichardt, Cassandra ; Beckmann, Joshua S. ; Adams, Zack W. ; Marusich, Julie A. ; Nesland, Travis O. ; Yates, Justin R. ; Kelly, Thomas H. ; Bardo, Michael T. / A translational behavioral model of mood-based impulsivity : Implications for substance abuse. In: Drug and Alcohol Dependence. 2012 ; Vol. 122, No. 1-2. pp. 93-99.
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