A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

Alexander Christov; William J. Kostuk; George Jablonsky; Paulette Desjardins; Ruth Courtis; Bernice Jardine; Anne Bailey; June Odlum-Blair; Janice Motiejunas; Sheila McConnell; Alexandra Lucas

doi:10.1117/12.409327

A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

Alexander Christov, William J. Kostuk, George Jablonsky, Paulette Desjardins, Ruth Courtis, Bernice Jardine, Anne Bailey, June Odlum-Blair, Janice Motiejunas, Sheila McConnell, Alexandra Lucas

Research output: Contribution to journal › Conference article › peer-review

Abstract

A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.

Original language	English (US)
Pages (from-to)	167-179
Number of pages	13
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4161
DOIs	https://doi.org/10.1117/12.409327
State	Published - 2000
Externally published	Yes
Event	Optical Biopsy and Tissue Optics - Amsterdam, Netherlands Duration: Jul 5 2000 → Jul 6 2000

Keywords

Angioplasty
Antiplatelet treatment
Membrane fluidity
Platelet activation

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.409327

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Christov, A., Kostuk, W. J., Jablonsky, G., Desjardins, P., Courtis, R., Jardine, B., Bailey, A., Odlum-Blair, J., Motiejunas, J., McConnell, S., & Lucas, A. (2000). A three tiered fluorescence-based system for monitoring activation-related changes in human platelets. Proceedings of SPIE - The International Society for Optical Engineering, 4161, 167-179. https://doi.org/10.1117/12.409327

Christov, A, Kostuk, WJ, Jablonsky, G, Desjardins, P, Courtis, R, Jardine, B, Bailey, A, Odlum-Blair, J, Motiejunas, J, McConnell, S & Lucas, A 2000, 'A three tiered fluorescence-based system for monitoring activation-related changes in human platelets', Proceedings of SPIE - The International Society for Optical Engineering, vol. 4161, pp. 167-179. https://doi.org/10.1117/12.409327

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abstract = "A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.",

keywords = "Angioplasty, Antiplatelet treatment, Membrane fluidity, Platelet activation",

author = "Alexander Christov and Kostuk, {William J.} and George Jablonsky and Paulette Desjardins and Ruth Courtis and Bernice Jardine and Anne Bailey and June Odlum-Blair and Janice Motiejunas and Sheila McConnell and Alexandra Lucas",

year = "2000",

doi = "10.1117/12.409327",

language = "English (US)",

volume = "4161",

pages = "167--179",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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T1 - A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

AU - Christov, Alexander

AU - Kostuk, William J.

AU - Jablonsky, George

AU - Desjardins, Paulette

AU - Courtis, Ruth

AU - Jardine, Bernice

AU - Bailey, Anne

AU - Odlum-Blair, June

AU - Motiejunas, Janice

AU - McConnell, Sheila

AU - Lucas, Alexandra

PY - 2000

Y1 - 2000

N2 - A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.

AB - A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.

KW - Angioplasty

KW - Antiplatelet treatment

KW - Membrane fluidity

KW - Platelet activation

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DO - 10.1117/12.409327

M3 - Conference article

AN - SCOPUS:18644385193

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EP - 179

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Optical Biopsy and Tissue Optics

Y2 - 5 July 2000 through 6 July 2000

ER -

A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

Abstract

Keywords

ASJC Scopus subject areas

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