A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

Alexander Christov, William J. Kostuk, George Jablonsky, Paulette Desjardins, Ruth Courtis, Bernice Jardine, Anne Bailey, June Odlum-Blair, Janice Motiejunas, Sheila McConnell, Alexandra Lucas

Research output: Contribution to journalConference articlepeer-review

Abstract

A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.

Original languageEnglish (US)
Pages (from-to)167-179
Number of pages13
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4161
DOIs
StatePublished - 2000
Externally publishedYes
EventOptical Biopsy and Tissue Optics - Amsterdam, Netherlands
Duration: Jul 5 2000Jul 6 2000

Keywords

  • Angioplasty
  • Antiplatelet treatment
  • Membrane fluidity
  • Platelet activation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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