TY - GEN
T1 - A T1 and DTI fused 3D Corpus Callosum analysis in pre-vs. Post-season contact sports players
AU - Lao, Yi
AU - Law, Meng
AU - Shi, Jie
AU - Gajawelli, Niharika
AU - Haas, Lauren
AU - Wang, Yalin
AU - Leporé, Natasha
N1 - Publisher Copyright:
© 2015 SPIE.
PY - 2015
Y1 - 2015
N2 - Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on callosal anatomy. In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes. Here, for the first time, we fuse T1 surface-based morphometry and a new DTI analysis on 3D surface representations of the CCs into a single statistical analysis on these subjects. Our new combined method successfully increases detection power in detecting differences between pre-vs. post-season contact sports players. Alterations are found in the ventral genu, isthmus, and splenium of CC. Our findings may inform future health assessments in contact sports players. The new method here is also the first truly multimodal diffusion and T1-weighted analysis of the CC, and may be useful to detect anatomical changes in the corpus callosum in other multimodal datasets.
AB - Sports related traumatic brain injury (TBI) is a worldwide public health issue, and damage to the corpus callosum (CC) has been considered as an important indicator of TBI. However, contact sports players suffer repeated hits to the head during the course of a season even in the absence of diagnosed concussion, and less is known about their effect on callosal anatomy. In addition, T1-weighted and diffusion tensor brain magnetic resonance images (DTI) have been analyzed separately, but a joint analysis of both types of data may increase statistical power and give a more complete understanding of anatomical correlates of subclinical concussions in these athletes. Here, for the first time, we fuse T1 surface-based morphometry and a new DTI analysis on 3D surface representations of the CCs into a single statistical analysis on these subjects. Our new combined method successfully increases detection power in detecting differences between pre-vs. post-season contact sports players. Alterations are found in the ventral genu, isthmus, and splenium of CC. Our findings may inform future health assessments in contact sports players. The new method here is also the first truly multimodal diffusion and T1-weighted analysis of the CC, and may be useful to detect anatomical changes in the corpus callosum in other multimodal datasets.
UR - http://www.scopus.com/inward/record.url?scp=84922986648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922986648&partnerID=8YFLogxK
U2 - 10.1117/12.2072600
DO - 10.1117/12.2072600
M3 - Conference contribution
AN - SCOPUS:84922986648
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - 10th International Symposium on Medical Information Processing and Analysis
A2 - Romero, Eduardo
A2 - Lepore, Natasha
PB - SPIE
T2 - 10th International Symposium on Medical Information Processing and Analysis
Y2 - 14 October 2014 through 16 October 2014
ER -