A Synthetic Strategy of Quantum Dot-Bioconjugate

Qiangbin Wang; Hao Yan; Dong Seo

doi:10.1109/INEC.2010.5424726

A Synthetic Strategy of Quantum Dot-Bioconjugate

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Quantum dots (QDs) have attracted tremendous interest in biological applications, such as bioimaging, biolabeling, and biosensing, because of their advantages over organic fluorophores at high quantum yield (QY), size-tunable narrow emission, photostability, etc. To date, various strategies have been developed to obtain water-soluble QDs and QD bioconjugates, but these commonly require multiple steps to obtain the final products. Herein, we present a simple and robust one-step method for creating stable, water-soluble QD and QD-biomolecule conjugates. We demonstrate the successful implementation of this strategy by using mercaptopropyl acid and DNA molecules as model systems, but expect this could also be extended to other types of biomolecules.

Original language	English (US)
Title of host publication	INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings
Pages	332-333
Number of pages	2
DOIs	https://doi.org/10.1109/INEC.2010.5424726
State	Published - May 5 2010
Event	2010 3rd International Nanoelectronics Conference, INEC 2010 - Hongkong, China Duration: Jan 3 2010 → Jan 8 2010

Publication series

Name	INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings

Other

Other	2010 3rd International Nanoelectronics Conference, INEC 2010
Country/Territory	China
City	Hongkong
Period	1/3/10 → 1/8/10

ASJC Scopus subject areas

Electrical and Electronic Engineering

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10.1109/INEC.2010.5424726

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Wang, Q, Yan, H & Seo, D 2010, A Synthetic Strategy of Quantum Dot-Bioconjugate. in INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings., 5424726, INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings, pp. 332-333, 2010 3rd International Nanoelectronics Conference, INEC 2010, Hongkong, China, 1/3/10. https://doi.org/10.1109/INEC.2010.5424726

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title = "A Synthetic Strategy of Quantum Dot-Bioconjugate",

abstract = "Quantum dots (QDs) have attracted tremendous interest in biological applications, such as bioimaging, biolabeling, and biosensing, because of their advantages over organic fluorophores at high quantum yield (QY), size-tunable narrow emission, photostability, etc. To date, various strategies have been developed to obtain water-soluble QDs and QD bioconjugates, but these commonly require multiple steps to obtain the final products. Herein, we present a simple and robust one-step method for creating stable, water-soluble QD and QD-biomolecule conjugates. We demonstrate the successful implementation of this strategy by using mercaptopropyl acid and DNA molecules as model systems, but expect this could also be extended to other types of biomolecules.",

author = "Qiangbin Wang and Hao Yan and Dong Seo",

year = "2010",

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doi = "10.1109/INEC.2010.5424726",

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series = "INEC 2010 - 2010 3rd International Nanoelectronics Conference, Proceedings",

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T1 - A Synthetic Strategy of Quantum Dot-Bioconjugate

AU - Wang, Qiangbin

AU - Yan, Hao

AU - Seo, Dong

PY - 2010/5/5

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N2 - Quantum dots (QDs) have attracted tremendous interest in biological applications, such as bioimaging, biolabeling, and biosensing, because of their advantages over organic fluorophores at high quantum yield (QY), size-tunable narrow emission, photostability, etc. To date, various strategies have been developed to obtain water-soluble QDs and QD bioconjugates, but these commonly require multiple steps to obtain the final products. Herein, we present a simple and robust one-step method for creating stable, water-soluble QD and QD-biomolecule conjugates. We demonstrate the successful implementation of this strategy by using mercaptopropyl acid and DNA molecules as model systems, but expect this could also be extended to other types of biomolecules.

AB - Quantum dots (QDs) have attracted tremendous interest in biological applications, such as bioimaging, biolabeling, and biosensing, because of their advantages over organic fluorophores at high quantum yield (QY), size-tunable narrow emission, photostability, etc. To date, various strategies have been developed to obtain water-soluble QDs and QD bioconjugates, but these commonly require multiple steps to obtain the final products. Herein, we present a simple and robust one-step method for creating stable, water-soluble QD and QD-biomolecule conjugates. We demonstrate the successful implementation of this strategy by using mercaptopropyl acid and DNA molecules as model systems, but expect this could also be extended to other types of biomolecules.

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A Synthetic Strategy of Quantum Dot-Bioconjugate

Abstract

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