TY - JOUR
T1 - A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis
AU - Montali, Lorenzo
AU - Tanaka, Atsushi
AU - Riva, Paolo
AU - Takahashi, Hiroki
AU - Cocchi, Claudio
AU - Ueno, Yoshiyuki
AU - Miglioretti, Massimo
AU - Takikawa, Hajime
AU - Vecchio, Luca
AU - Frigerio, Alessandra
AU - Bianchi, Ilaria
AU - Jorgensen, Roberta
AU - Lindor, Keith D.
AU - Podda, Mauro
AU - Invernizzi, Pietro
N1 - Funding Information:
Grant support: Supported by Executive Program of Cooperation in the Field of Science and Technology between the Government of Italy and the Government of Japan.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - Background: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. Aims: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. Methods: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). Results: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. Conclusion: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients.
AB - Background: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. Aims: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. Methods: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). Results: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. Conclusion: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients.
KW - Factor structure
KW - PBC-40
KW - Principal component analysis
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=77956288031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956288031&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2010.01.004
DO - 10.1016/j.dld.2010.01.004
M3 - Article
C2 - 20163995
AN - SCOPUS:77956288031
SN - 1590-8658
VL - 42
SP - 718
EP - 723
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 10
ER -