A sequential algorithm for the non-linear dual-sorption model of percutaneous drug absorption

Abba Gumel, K. Kubota, E. H. Twizell

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A sequential algorithm is developed for the non-linear dual-sorption model developed by Chandrasekaran et al. [1,2] which monitors pharmacokinetic profiles in percutaneous drug absorption. In the experimental study of percutaneous absorption, it is often observed that the lag-time decreases with the increase in the donor concentration when two or more donor concentrations of the same compound are used. The dual-sorption model has sometimes been employed to explain such experimental results. In this paper, it is shown that another feature observed after vehicle removal may also characterize the dual-sorption model. Soon after vehicle removal, the plots of the drug flux versus time become straight lines on a semilogarithmic scale as in the linear model, but the half-life is prolonged thereafter when the dual-sorption model prevails. The initial half-life after vehicle removal with a low donor concentration is longer than that with a higher donor concentration. These features, if observed in experiments, may be used as evidence to confirm that the dual-sorption model gives an explanation to the non-linear kinetic behaviour of a permeant.

Original languageEnglish (US)
Pages (from-to)87-103
Number of pages17
JournalMathematical Biosciences
Volume152
Issue number1
DOIs
StatePublished - Aug 15 1998
Externally publishedYes

Fingerprint

Skin Absorption
Sorption
Sequential Algorithm
pharmacokinetics
sorption
Half-Life
Drugs
drug
Absorption
Pharmaceutical Preparations
Linear Models
Pharmacokinetics
half life
Model
Time Lag
Straight Line
Experimental Study
Linear Model
Monitor
Kinetics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics

Cite this

A sequential algorithm for the non-linear dual-sorption model of percutaneous drug absorption. / Gumel, Abba; Kubota, K.; Twizell, E. H.

In: Mathematical Biosciences, Vol. 152, No. 1, 15.08.1998, p. 87-103.

Research output: Contribution to journalArticle

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